Background Peptic ulcer is an excoriated area of stomach or intestinal mucosa. Two experimental designs were proceeded: the first aimed. on twenty adult male albino rats, used to study the protective effect of both ranitidine and nizatidine; on the second, including sixty adult male albino rats, was used to study the therapeutic effect of ranitidine and nizatidine after induction of ulcer and also to evaluate the adverse effects of therapeutic doses of H2-receptor antagonists on male hormonal profile. The study aims to assess the gastroprotective effects of nizatidine and ranitidine and on treating of non-steroidal anti-inflammatory drugs (NSAIDs) induced peptic ulcer and to evaluate its adverse effect on male sex hormones. Result The result revealed that ranitidine and nizatidine reduced incidence of ulceration. Histopathological findings showed a significant recovery of the alteration, and disturbance in male sex hormones. Conclusion Nizatidine is better than ranitidine in the management of NSAIDs induced peptic ulcer in rats.

中文翻译：

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雷尼替丁和尼扎替丁治疗消化性溃疡的比较组织学和组织化学研究及其对男性性激素的不良影响

背景 消化性溃疡是胃或肠黏膜脱落的区域。进行了两个实验设计：第一个目标。在二十只成年雄性白化大鼠身上，用于研究雷尼替丁和尼扎替丁的保护作用；第二个，包括 60 只成年雄性白化大鼠，用于研究雷尼替丁和尼扎替丁在诱导溃疡后的治疗效果，并评估治疗剂量的 H2 受体拮抗剂对雄性激素谱的不利影响。该研究旨在评估尼扎替丁和雷尼替丁的胃保护作用以及治疗非甾体抗炎药 (NSAIDs) 诱发的消化性溃疡，并评估其对男性性激素的不利影响。结果 结果表明，雷尼替丁和尼扎替丁可降低溃疡发生率。组织病理学发现显着恢复了男性性激素的改变和紊乱。结论 尼扎替丁对非甾体抗炎药所致大鼠消化性溃疡的治疗效果优于雷尼替丁。