Among the DNA tumor viruses Epstein-Barr virus (EBV) and Kaposi sarcoma herpesvirus (KSHV), account for a considerable percentage of virus-associated cancers. Deregulation of transcription factors signaling pathways is one of the most significant oncogenic characteristics of EBV and KSHV. NF-κB is a transcription factor that play a remarkable role in oncogenesis because of its function as a master regulator of a spectrum of genes involved in physiological and pathophysiological process. Constitutive activation of NF-κB is a frequent and well-described event in many human malignancies. Compelling evidence represent EBV and KSHV are capable of targeting different components of NF-κB cascade. Here, we summarized recent findings to clarify the precise relationship between dysregulation of NF-κB and EBV and KSHV-related malignancies. This essay also emphasizes on contribution of various viral products in developing cancer through alteration of NF-κB signaling pathway.

中文翻译：

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EBV 和 KSHV 病毒产物与 NF-κB 通路在肿瘤发生中的相互作用

在 DNA 肿瘤病毒 Epstein-Barr 病毒 (EBV) 和卡波西肉瘤疱疹病毒 (KSHV) 中，占病毒相关癌症的相当大比例。转录因子信号通路的失调是 EBV 和 KSHV 最重要的致癌特征之一。NF-κB 是一种转录因子，由于其作为参与生理和病理生理过程的一系列基因的主要调节因子而在肿瘤发生中起显着作用。在许多人类恶性肿瘤中，NF-κB 的组成性激活是一种常见且已被充分描述的事件。令人信服的证据表明 EBV 和 KSHV 能够靶向 NF-κB 级联的不同成分。在这里，我们总结了最近的发现，以阐明 NF-κB 和 EBV 失调与 KSHV 相关恶性肿瘤之间的确切关系。