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Full-spectrum responsive ZrO2-based phototheranostic agent for NIR-II photoacoustic imaging-guided cancer phototherapy
Biomaterials Science ( IF 5.8 ) Pub Date : 2020-10-15 , DOI: 10.1039/d0bm01482f Chengyuan Zhu 1, 2, 3, 4, 5 , Zhaoyang Ding 1, 2, 3, 4, 5 , Zhengxi Guo 1, 2, 3, 4, 5 , Xiaolu Guo 1, 2, 3, 4, 5 , Aijia Yang 1, 2, 3, 4, 5 , Zhilang Li 1, 2, 3, 4, 5 , Bang-Ping Jiang 1, 2, 3, 4, 5 , Xing-Can Shen 1, 2, 3, 4, 5
Biomaterials Science ( IF 5.8 ) Pub Date : 2020-10-15 , DOI: 10.1039/d0bm01482f Chengyuan Zhu 1, 2, 3, 4, 5 , Zhaoyang Ding 1, 2, 3, 4, 5 , Zhengxi Guo 1, 2, 3, 4, 5 , Xiaolu Guo 1, 2, 3, 4, 5 , Aijia Yang 1, 2, 3, 4, 5 , Zhilang Li 1, 2, 3, 4, 5 , Bang-Ping Jiang 1, 2, 3, 4, 5 , Xing-Can Shen 1, 2, 3, 4, 5
Affiliation
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Second near-infrared (NIR-II) window responsive phototheranostic agents have a precise spatiotemporal potential for the diagnosis and treatment of cancer. In this study, a full-spectrum responsive ZrO2-based phototheranostic agent was found to achieve NIR-II photoacoustic (PA) imaging-guided tumour-targeting phototherapy. Initially, the ZrO2-based phototheranostic agent was fabricated through NaBH4 reduction to form boron-doped oxygen-deficient zirconia (ZrO2−x-B), an amino-functionalised SiO2 shell and a further covalent connection with hyaluronic acid (HA), namely, ZrO2−x-B@SiO2-HA. In the ZrO2−x-B@SiO2-HA system, the oxygen vacancy and boron doping resulted in full-spectrum absorption, enabling a high NIR-II photothermal conversion, high-resolution PA imaging ability and a remarkable production of reactive oxygen species (ROS). The surface modification of HA provided ZrO2−x-B@SiO2-HA with water dispersibility and a targeting capability for CD44 overexpressed cancer cells. Furthermore, in vitro and in vivo experiments showed that NIR-II activated ZrO2−x-B@SiO2-HA had a targeted photothermal/photodynamic effect for cancer elimination under the real-time guidance of NIR-II PAs. Hence, ZrO2−x-B@SiO2-HA displays a precise NIR-II radiation-activated phototheranostic potential for PA imaging-guided cancer-targeting photothermal/photodynamic therapy.
中文翻译：
基于光谱的基于ZrO2的全光谱光热疗剂，用于NIR-II光声成像引导的癌症光疗
第二种近红外（NIR-II）窗口响应型光热敏剂在诊断和治疗癌症方面具有精确的时空潜力。在这项研究中，发现基于全光谱的基于ZrO 2的光热疗剂可实现NIR-II光声（PA）成像引导的肿瘤靶向光疗。最初，通过NaBH 4还原制备ZrO 2基光热敏剂，形成硼掺杂的缺氧氧化锆（ZrO 2- x -B），氨基官能化的SiO 2壳并与透明质酸（HA）进一步共价连接。 ），即ZrO 2- x -B @ SiO 2 -HA。在ZrO 2− x中-B @ SiO 2 -HA系统中的氧空位和硼掺杂导致全光谱吸收，从而实现了高NIR-II光热转换，高分辨率PA成像能力和显着的活性氧（ROS）产生。HA的表面修饰为ZrO 2- x -B @ SiO 2 -HA提供了水分散性和对CD44过表达的癌细胞的靶向能力。此外，体外和体内实验表明，在NIR-II PA的实时指导下，NIR-II活化的ZrO 2 - x -B @ SiO 2 -HA具有消除癌症的靶向光热/光动力作用。因此，ZrO 2- x-B @ SiO 2 -HA具有精确的NIR-II辐射激活光热能潜能，可用于PA成像引导的靶向癌症的光热/光动力疗法。
更新日期：2020-11-03
中文翻译：
基于光谱的基于ZrO2的全光谱光热疗剂，用于NIR-II光声成像引导的癌症光疗
第二种近红外（NIR-II）窗口响应型光热敏剂在诊断和治疗癌症方面具有精确的时空潜力。在这项研究中，发现基于全光谱的基于ZrO 2的光热疗剂可实现NIR-II光声（PA）成像引导的肿瘤靶向光疗。最初，通过NaBH 4还原制备ZrO 2基光热敏剂，形成硼掺杂的缺氧氧化锆（ZrO 2- x -B），氨基官能化的SiO 2壳并与透明质酸（HA）进一步共价连接。 ），即ZrO 2- x -B @ SiO 2 -HA。在ZrO 2− x中-B @ SiO 2 -HA系统中的氧空位和硼掺杂导致全光谱吸收，从而实现了高NIR-II光热转换，高分辨率PA成像能力和显着的活性氧（ROS）产生。HA的表面修饰为ZrO 2- x -B @ SiO 2 -HA提供了水分散性和对CD44过表达的癌细胞的靶向能力。此外，体外和体内实验表明，在NIR-II PA的实时指导下，NIR-II活化的ZrO 2 - x -B @ SiO 2 -HA具有消除癌症的靶向光热/光动力作用。因此，ZrO 2- x-B @ SiO 2 -HA具有精确的NIR-II辐射激活光热能潜能，可用于PA成像引导的靶向癌症的光热/光动力疗法。
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