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Aloperine Induces Apoptosis by a Reactive Oxygen Species Activation Mechanism in Human Ovarian Cancer Cells
Protein & Peptide Letters ( IF 1.0 ) Pub Date : 2020-08-31 , DOI: 10.2174/0929866527666200320094313 Mingning Qiu 1 , Jie Liu 1 , Yongxia Su 1 , Jianjun Liu 2 , Chenchen Wu 1 , Baoyu Zhao 1
中文翻译：
Aloperine通过人类卵巢癌细胞中的活性氧激活机制诱导凋亡。
更新日期：2020-10-16
Protein & Peptide Letters ( IF 1.0 ) Pub Date : 2020-08-31 , DOI: 10.2174/0929866527666200320094313 Mingning Qiu 1 , Jie Liu 1 , Yongxia Su 1 , Jianjun Liu 2 , Chenchen Wu 1 , Baoyu Zhao 1
Affiliation
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Background: Ovarian cancer is the most lethal gynecologic malignancy worldwide with poor prognosis owing to chemotherapy resistance and cancer relapse. Hence, there is an urgent need to develop novel anticancer agents against ovarian cancer.
Objective: The aim of this research is to investigate the possible anticancer activity of aloperine, an active ingredient from a traditional Chinese medicine Sophora alopecuroides, and to explore the possible Reactive Oxygen Species (ROS)-related mechanism.中文翻译：
Aloperine通过人类卵巢癌细胞中的活性氧激活机制诱导凋亡。
背景：卵巢癌是全球最致命的妇科恶性肿瘤，由于化疗耐药和癌症复发，预后较差。因此，迫切需要开发针对卵巢癌的新型抗癌药。
目的：本研究的目的是研究苦参碱（一种来自中药苦豆碱的有效成分）的可能的抗癌活性，并探讨其可能与活性氧（ROS）相关的机制。
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