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Deciphering of The Effect of Chemotherapeutic Agents on Human Glutathione S-Transferase Enzyme and MCF-7 Cell Line
Protein & Peptide Letters ( IF 1.0 ) Pub Date : 2020-08-31 , DOI: 10.2174/0929866527666200413101017
Havva Aybek 1 , Yusuf Temel 2 , Barzan Mirza Ahmed 3 , Can Ali Ağca 4 , Mehmet Çiftci 1
Affiliation  

Background: Cancer is the disease that causes the most death after cardiovascular diseases all over the world these days. Breast cancer is the most common type of cancer among women and ranks the second among cancer-related deaths after lung cancer. Chemotherapeutics act by killing cancer cells, preventing their spread and slowing their growth. Recent studies focus on the effects of chemotherapeutics on cancer cells and new chemotherapy approaches that targeting enzymes that catalyze important metabolic reactions in the cell.

Objective: The aim of this study was to investigate the effects of chemotherapeutic agents, Tamoxifen and 5-FU, on MCF-7 cell line and human erythrocyte GST, an important enzyme of intracellular antioxidant metabolism.


中文翻译:

解读化学治疗剂对人谷胱甘肽S-转移酶和MCF-7细胞系的影响

背景:癌症是当今世界上导致心血管疾病死亡人数最多的疾病。乳腺癌是女性中最常见的癌症,在仅次于肺癌的癌症相关死亡中排名第二。化学疗法的作用是杀死癌细胞,阻止其扩散并减慢其生长。最近的研究集中于化学疗法对癌细胞的影响和针对靶向催化细胞中重要代谢反应的酶的新化学疗法。

目的:本研究旨在探讨化学治疗剂三苯氧胺和5-FU对MCF-7细胞系和人红细胞GST(细胞内抗氧化剂代谢的重要酶)的影响。
更新日期:2020-10-16
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