A disintegrin and metallopeptidase with thrombospondin motifs (ADAMTSs), which is frequently dysregulated in cancers and is involved in carcinogenesis and cancer progression. The present study identified that ADAMTS8 expression is downregulated in esophageal squamous cell carcinoma (ESCC) tissues when compared with nontumor tissue. The expression of ADAMTS8 is closely associated with clinical stage and lymph node metastasis in patients with ESCC. Furthermore, functional studies have shown that ADAMTS8 overexpression could reduce abilities of proliferation, migration, and invasion and promote apoptosis of ESCC cells. Meanwhile, monocyte chemotactic protein-1 and interleukin-6 are markedly deregulated by ADAMTS8 overexpression. Consistently, in vivo data showed that ADAMTS8 overexpression led to a reduction in tumor growth. These results indicate that altering ADAMTS8 expression could modify the outcomes of ESCC by inhibiting cell proliferation and invasion, while promoting the apoptosis of ECSS cells. Thus, ADAMTS8 represents a potential therapeutic target for ESCC therapy.

中文翻译：

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ADAMTS8 抑制食管鳞状细胞癌的进展


一种具有血小板反应蛋白基序 (ADAMTS) 的解整合素和金属肽酶，在癌症中经常失调，并参与癌发生和癌症进展。本研究发现，与非肿瘤组织相比，ADAMTS8 表达在食管鳞状细胞癌 (ESCC) 组织中下调。 ADAMTS8的表达与ESCC患者的临床分期和淋巴结转移密切相关。此外，功能研究表明ADAMTS8过表达可降低ESCC细胞的增殖、迁移和侵袭能力，促进细胞凋亡。同时， ADAMTS8过表达显着失调单核细胞趋化蛋白 1 和白细胞介素 6。体内数据一致表明， ADAMTS8过度表达会导致肿瘤生长减少。这些结果表明，改变ADAMTS8表达可以通过抑制细胞增殖和侵袭，同时促进 ECSS 细胞凋亡来改变 ESCC 的结果。因此， ADAMTS8代表了 ESCC 治疗的潜在治疗靶点。