The aim of this study was to evaluate the physicochemical properties of experimental adhesives containing tailored fluoridated calcium phosphate fillers. Five experimental resins were formulated, one contained no calcium phosphate filler (Control) and the other four resins contained 40 wt% of calcium phosphate fillers doped with increasing concentrations of fluoride: adhesives CaP (no fluoride), CaP-2F (2 wt% F), CaP-4F (4 wt% F), and CaP-8F (8 wt% F). Resin specimens were prepared for a three-point bending test to evaluate the elastic modulus (E) and flexural strength (FS) at 24 h and after 2 months of water storage. Disk-shaped specimens were prepared to analyze the water sorption (Ws) according to ISO 4049. The degree of conversion (DC) of the tested resins was also assessed through FTIR. Statistical analysis was performed with ANOVA and Tukey’s test (p < 0.05). The addition of F-CaP particles at 0 and 2 wt% fluoride had no effect on the DC (p > 0.05) compared to the filler-free resin. However, these same experimental resins showed the highest E after water storage. All resins had a significant reduction of the FS after water storage (p < 0.001), but at a lower percentage rate for those experimental resins containing fluoride-free CaP or fluoride-doped CaP-2F. These latter experimental resins achieved similar Ws to control the filler-free resin. Conversely, those resins containing 4 or 8 wt% fluoride-doped CaP had a significant Ws increase (p < 0.05). In conclusion, the incorporation of calcium phosphate particles without fluoride or with 2 wt% fluoride may represent a promising strategy to generate adhesive resins with specific physicochemical properties. Fluoride incorporation in CaP fillers for dental resin adhesive should be performed at low concentrations in order to avoid excessive water sorption and a decrease of polymerization.

这项研究的目的是评估含有量身定制的氟化磷酸钙填料的实验粘合剂的理化性质。配制了五种实验树脂，一种不含磷酸钙填充剂（对照），另一种树脂含有40 wt％的磷酸钙填充剂，掺杂了增加的氟化物浓度：粘合剂CaP（无氟化物），CaP-2F（2 wt％F ），CaP-4F（4 wt％F）和CaP-8F（8 wt％F）。制备树脂样品进行三点弯曲试验，以评估储水2个月后24小时的弹性模量（E）和弯曲强度（FS）。根据ISO 4049，准备了盘状样品以分析吸水率（Ws）。还通过FTIR评估了测试树脂的转化率（DC）。p<0.05）。添加氟化物含量为0和2 wt％的F-CaP颗粒对DC无影响（p> 0.05）与无填料树脂相比。然而，这些相同的实验树脂在储水后显示出最高的E。储水后，所有树脂的FS均显着降低（p<0.001），但是对于那些包含无氟CaP或掺杂氟的CaP-2F的实验树脂而言，百分比较低。这些后面的实验树脂达到了类似的Ws，以控制无填料的树脂。相反，含有4或8 wt％氟化物掺杂的CaP的那些树脂的Ws明显增加（p<0.05）。总之，掺入不含氟化物或含2 wt％氟化物的磷酸钙颗粒可能代表了一种产生具有特定物理化学性质的粘性树脂的有前途的策略。牙科树脂粘合剂的CaP填料中应掺入低浓度的氟，以避免过多的水吸收和聚合反应的减少。