Frontiers in Cellular and Infection Microbiology ( IF 4.6 ) Pub Date : 2020-09-30 , DOI: 10.3389/fcimb.2020.585791 Elaine I Tuomanen 1
Highly successful invasive pathogens exploit host vulnerabilities by adapting tools to co-opt highly conserved host features. This is especially true when pathogens develop ligands to hijack trafficking routes or signaling patterns of host receptors. In this context, highly successful pathogens can be grouped together by the patterns of organs infected and diseases they cause. In the case of this perspective, the focus is on the historically most successful invasive bacterial pathogens of children that cause pneumonia, sepsis and meningitis:
中文翻译:
儿科医生的观点:儿童三种最成功的病原体的共同发病机理
高度成功的侵入性病原体通过改编工具以选择高度保守的宿主特征来利用宿主漏洞。当病原体形成配体以劫持宿主受体的运输路线或信号传导模式时,尤其如此。在这种情况下,可以将高度成功的病原体按感染器官的类型和它们引起的疾病进行分类。在这种情况下,重点是导致儿童历史上最成功的导致肺炎,败血症和脑膜炎的侵入性细菌病原体: