Toxoplasma gondii is an exceptionally successful parasite that infects a very broad host range, including humans, across the globe. The outcome of infection differs remarkably between hosts, ranging from acute death to sterile infection. These differential disease patterns are strongly influenced by both host- and parasite-specific genetic factors. In this review, we discuss how the clinical outcome of toxoplasmosis varies between hosts and the role of different immune genes and parasite virulence factors, with a special emphasis on Toxoplasma-induced ileitis and encephalitis.

中文翻译：

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弓形虫感染期间宿主和寄生虫菌株对免疫反应的影响

弓形虫是一种非常成功的寄生虫，可感染全球范围内非常广泛的宿主，包括人类。宿主之间的感染结果差异很大，从急性死亡到无菌感染。这些不同的疾病模式受到宿主和寄生虫特异性遗传因素的强烈影响。在这篇综述中，我们讨论了弓形虫病的临床结果如何因宿主而异，以及不同免疫基因和寄生虫毒力因子的作用，特别强调弓形虫引起的回肠炎和脑炎。