The janus kinase (JAK)/signal transducer and activator of transcription (STAT) signaling pathway is associated with the regulation of essential cellular mechanisms, such as proliferation, invasion, survival, inflammation, and immunity. Aberrant JAK/STAT signaling contributes to cancer progression and metastatic development. STAT proteins play an essential role in the development of cervical cancer, and the inhibition of the JAK/STAT pathway may be essential for enhancing tumor cell death. Persistent activation of different STATs is present in a variety of cancers, including cervical cancer, and their overactivation may be associated with a poor prognosis and poor overall survival. The oncoproteins E6 and E7 play a critical role in the progression of cervical cancer and may mediate the activation of the JAK/STAT pathway. Inhibition of STAT proteins appears to show promise for establishing new targets in cancer treatment. The present review summarizes the knowledge about the participation of the different components of the JAK/STAT pathway and the participation of the human papillomavirus (HPV) associated with the process of cellular malignancy.

中文翻译：

---

JAK / STAT通路在宫颈癌中的作用：与HPV E6 / E7癌蛋白的关系

janus激酶（JAK）/信号转导子和转录激活子（STAT）信号通路与基本细胞机制的调节相关，例如增殖，侵袭，存活，炎症和免疫力。异常的JAK / STAT信号传导有助于癌症进展和转移性发展。STAT蛋白在宫颈癌的发展中起着至关重要的作用，而JAK / STAT通路的抑制可能对于增强肿瘤细胞的死亡至关重要。在包括宫颈癌在内的多种癌症中都存在不同STATs的持续活化，其过度活化可能与不良预后和较差的总体生存率有关。癌蛋白E6和E7在宫颈癌的进展中起关键作用，并可能介导JAK / STAT通路的激活。抑制STAT蛋白似乎显示出在癌症治疗中建立新靶标的希望。本综述总结了有关JAK / STAT途径的不同组成部分以及与细胞恶性肿瘤过程相关的人乳头瘤病毒（HPV）参与的知识。