Synovial sarcoma (SS) is a malignant mesenchymal soft tissue neoplasm. Despite its name, the cells of origin are not synovial cells, but rather neural, myogenic, or multipotent mesenchymal stem cells have been proposed as possible cells originators. Unlike other sarcomas, an unusual presentation of long-term pain at the tumor site has been documented, but the exact mechanisms have not been fully clarified yet. The transient receptor potential ankyrin 1 (TRPA1) is a nonselective cation channel mainly expressed in primary sensory neurons, where it functions as a pain sensor. TRPA1 have also been described in multiple non-excitable cells, including those derived from neural crest stem cells such as glial cells and, in particular, Schwann cell oligodendrocytes and astrocytes. We evaluated TRPA1 expression in SS. We selected a cohort of 41 SSs, and by immunohistochemistry, we studied TRPA1 expression. TRPA1 was found in 92.6% of cases. Triple TRPA1/pS100/SOX10 and TRPA1/SLUG/SNAIL staining strongly supports a neural origin of SS. TRPA1 positivity was also observed in a subset of cases negative with pS100, SOX10 and/or SLUG/SNAIL, and these divergent phenotypes may reflect a process of tumor plasticity and dedifferentiation of neural-derived SSs. Given the functional diversity of TRPA1 and its expression in neuronal and non-neuronal multipotent neural crest stem cells, it remains to be determined whether TRPA1 expression in SSs neoplastic cells plays a role in the molecular mechanism associated with premonitory pain symptoms and tumor progression.

中文翻译：

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滑膜肉瘤中TRPA1表达可能支持神经起源。

滑膜肉瘤（SS）是一种恶性间质软组织肿瘤。尽管它的名字，起源细胞不是滑膜细胞，而是神经，成肌或多能的间充质干细胞被认为是可能的细胞起源。与其他肉瘤不同，已记录了肿瘤部位长期疼痛的异常表现，但确切的机制尚未完全阐明。瞬时受体电位锚蛋白1（TRPA1）是主要在初级感觉神经元中表达的非选择性阳离子通道，在该通道中它起着疼痛传感器的作用。还已经在多种非兴奋性细胞中描述了TRPA1，包括源自神经c干细胞的那些，例如神经胶质细胞，特别是雪旺氏细胞少突胶质细胞和星形胶质细胞。我们评估了SS中TRPA1的表达。我们选择了41个SS群组，。在92.6％的病例中发现了TRPA1。TRPA1 / pS100 / SOX10和TRPA1 / SLUG / SNAIL的三重染色强烈支持SS的神经起源。在pS100，SOX10和/或SLUG / SNAIL阴性的亚型病例中也观察到TRPA1阳性，这些不同的表型可能反映了肿瘤可塑性和神经源性SS脱分化的过程。鉴于TRPA1的功能多样性及其在神经元和非神经元多能性神经c干细胞中的表达，尚需确定SSs肿瘤细胞中TRPA1的表达是否在与先兆性疼痛症状和肿瘤进展相关的分子机制中起作用。