Phenolic compounds are one of the most widespread classes of compounds in nature, with several beneficial biological effects being associated with their anti-oxidant and anti-carcinogenic activities. Their application in the prevention or treatment of numerous chronic diseases have been studied, but a major drawback is still the low bioavailability of these compounds, as well as their instability towards pH, temperature, and light in some cases. Nanotechnology has emerged as an alternative to overcome these limitations, and the use of lipidic encapsulation systems is a promising technique to achieve an efficient drug delivery, protecting molecules from external factors and improving their bioavailability. In this review, solid lipid nanoparticles and nanostructured lipid carriers are highlighted as an important tool for the improvement of the bioavailability and stability of natural phenolic compounds, including their preparation methods and functionalization approaches and the discussion of several applications for putative use in cosmetic and pharmacologic products.

中文翻译：

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固体脂质纳米颗粒作为天然酚类化合物的载体


酚类化合物是自然界中最广泛存在的一类化合物，其多种有益的生物效应与其抗氧化和抗癌活性相关。人们已经研究了它们在预防或治疗多种慢性疾病中的应用，但主要缺点仍然是这些化合物的生物利用度低，以及在某些情况下它们对pH、温度和光的不稳定性。纳米技术已成为克服这些限制的替代方案，并且使用脂质封装系统是一种有前途的技术，可以实现有效的药物输送，保护分子免受外部因素的影响并提高其生物利用度。在这篇综述中，固体脂质纳米粒子和纳米结构脂质载体被强调为提高天然酚类化合物的生物利用度和稳定性的重要工具，包括它们的制备方法和功能化方法，以及在化妆品和药理学中的几种假定应用的讨论产品。