Abstract

In current research study, novel chitosan-based hydrogel was formulated via crosslinking graft copolymerization of acrylic acid (AA) and chitosan. Potassium persulfate was used as free radical generator in the presence of crosslinker (methylene bis acrylamide (MBA)). FTIR spectroscopy was employed to elucidate structure of hydrogel. Moreover, sample morphology was examined by scanning electron microscopy (SEM) and thermal analysis was conducted by using thermogravimetric analysis (DSC/TGA). The influence of reaction variables such as concentration of chitosan (CS), acrylic acid (AA) and MBA was optimized to attain hydrogel with significant swelling capacity. Chitosan-g-AA hydrogel depicted pH responsive attributes and swelling–deswelling pulsatile behavior was recorded at pHs 1.2 and 7.4. This on–off switching makes hydrogel ideal candidate for controlled drug delivery.

摘要

在目前的研究中，通过丙烯酸（AA）和壳聚糖的交联接枝共聚制备了新型壳聚糖基水凝胶。过硫酸钾在交联剂（亚甲基双丙烯酰胺（MBA））。FTIR光谱用于阐明水凝胶的结构。此外，通过扫描电子显微镜（SEM）检查样品形态，并通过使用热重分析（DSC / TGA）进行热分析。优化反应变量的影响，例如壳聚糖 (CS)、丙烯酸 (AA) 和 MBA 的浓度，以获得具有显着溶胀能力的水凝胶。壳聚糖-g-AA 水凝胶描绘了 pH 响应属性，并且在 pH 值 1.2 和 7.4 下记录了溶胀-去溶胀的脉动行为。这种开关切换使水凝胶成为受控药物输送的理想候选者。