Objective: Brain-derived neurotrophic factor (BDNF) has beneficial effects on metabolism as well as the peripheral and central nervous systems. The aim of this study was to assess the response of serum BDNF concentration ([BDNF]s) to wheelchair half marathon race in individuals with spinal cord injury (SCI).

Design: Prospective observational study.

Setting: The 34th Oita International Wheelchair Marathon Race in Japan.

Participants: Nine cervical SCIs (CSCI) and 8 thoracic and lumber SCIs (LSCI) male athletes. Interventions: Wheelchair half-Marathon Race.

Outcome measures: [BDNF]s, plasma concentrations of adrenaline ([Ad]p), noradrenaline ([Nor]p), and cortisol ([Cor]p), hematocrit, and platelet count were measured the day before, immediately after, and an hour after the race.

Results: [BDNF]s increased significantly immediately after the race in both groups (CSCI; P = 0.0055, LSCI; P = 0.0312) but returned to the baseline levels at one hour after the race. However, [BDNF]s immediately and one hour after the race were significantly higher in LSCI than in CSCI (immediately after the race; P = 0.0037, 1 h after the race; P = 0.0206). Hematocrit and platelet count remained unchanged throughout the study. In LSCI, [Ad]p, [Nor]p and [Cor]p increased significantly immediately after and one hour after the race, compared with the baseline values (P < 0.05). On the other hand, these variables remained unchanged throughout the study in the CSCI.

Conclusions: [BDNF]_s increased significantly from the baseline in both LCSI and CSCI but was higher in LSCI than in CSCI immediately after and one hour after the race.

目的：脑源性神经营养因子 (BDNF) 对新陈代谢以及外周和中枢神经系统具有有益作用。本研究的目的是评估脊髓损伤 (SCI) 患者血清 BDNF 浓度 ([BDNF]s) 对轮椅半程马拉松比赛的反应。

设计：前瞻性观察研究。

地点：日本第34届大分国际轮椅马拉松比赛。

参与者： 9 名颈部 SCI (CSCI) 和 8 名胸部和腰部 SCI (LSCI) 男性运动员。干预措施：轮椅半程马拉松比赛。

结果测量：在前一天、之后立即测量 [BDNF]、肾上腺素 ([Ad]p)、去甲肾上腺素 ([Nor]p) 和皮质醇 ([Cor]p) 的血浆浓度、血细胞比容和血小板计数，比赛结束后一个小时。

结果：两组的[BDNF]在赛后立即显着增加（CSCI；P = 0.0055，LSCI；P = 0.0312），但在赛后一小时恢复到基线水平。然而，LSCI 中和赛后一小时的 [BDNF] 显着高于 CSCI（赛后立即；P = 0.0037，赛后 1 小时；P = 0.0206）。在整个研究过程中，血细胞比容和血小板计数保持不变。在 LSCI 中，与基线值相比，[Ad]p、[Nor]p 和 [Cor]p 在赛后立即和赛后一小时显着增加（P < 0.05）。另一方面，这些变量在整个 CSCI 研究中保持不变。

结论：在 LCSI 和 CSCI 中， [BDNF] _s从基线显着增加，但在赛后立即和赛后一小时，LSCI 中的比 CSCI 更高。