Abstract In this study, the electrospinning machine was developed with a liquid bath support system, which is capable to achieve randomly organized three dimensional (3D) nanofibrous structure. These structures were fabricated using high speed stirring for liquid bath collector system resulting in fluffy and glibly structures. To investigate the optimal electrospinning conditions, as well as parameters like voltage, flow rate, distance between the electrodes with respect to polymer solution properties of poly(butylene succinate) (PBS), a series of experiments, were conducted. It was found that solution properties, such as combination of solvents, concentration of PBS, had significant effect on fiber morphology. The resultant scaffold can satisfy requirement of structural properties such as macroscopic external shapes, internal architectures, porosity, and pore size. The structure and morphology of the nanofibrous scaffold were characterized by SEM. Hydrolytic degradation was studied for 2D as well as 3D nanofibrous scaffolds. Our study encourages utilizing bio-PBS based nanofibrous scaffolds to have a great degree in biomimetic structures.

中文翻译：

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用于仿生结构的3D生物聚丁二酸丁二醇酯静电纺纳米纤维支架

摘要 在本研究中，静电纺丝机采用液浴支撑系统开发，能够实现随机组织的三维（3D）纳米纤维结构。这些结构是使用高速搅拌液浴收集器系统制造的，从而产生蓬松和光滑的结构。为了研究最佳静电纺丝条件以及诸如电压、流速、电极之间的距离等参数与聚丁二酸丁二醇酯 (PBS) 的聚合物溶液特性有关，进行了一系列实验。发现溶液性质，如溶剂组合、PBS 浓度，对纤维形态有显着影响。所得支架可以满足结构特性的要求，如宏观外部形状、内部结构、孔隙率和孔径。通过SEM表征纳米纤维支架的结构和形态。研究了 2D 和 3D 纳米纤维支架的水解降解。我们的研究鼓励利用基于生物 PBS 的纳米纤维支架在仿生结构方面具有很大的作用。