Long noncoding RNAs (lncRNAs) have emerged as key regulators in a variety of cellular processes that influence disease states. In particular, many lncRNAs are genetically or epigenetically deregulated in cancer. However, whether lncRNA alterations are passengers acquired during cancer progression or can act as tumorigenic drivers is a topic of ongoing investigation. In this review, we examine the current methodologies underlying the identification of cancer‐associated lncRNAs and highlight important considerations for evaluating their biological significance as cancer drivers.

中文翻译：

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癌症中功能性长非编码 RNA 的鉴定和表征


长非编码 RNA (lncRNA) 已成为影响疾病状态的各种细胞过程的关键调节因子。特别是，许多 lncRNA 在癌症中发生遗传或表观遗传失调。然而，lncRNA 改变是否是癌症进展过程中获得的乘客，或者是否可以作为致瘤驱动因素，是一个正在进行的研究主题。在这篇综述中，我们研究了当前识别癌症相关 lncRNA 的方法，并强调了评估其作为癌症驱动因素的生物学意义的重要考虑因素。