Poly (rC)‐binding protein 1 (PCBP1), an RNA‐ or DNA‐binding protein with a relative molecular weight of 38 kDa, which is characterized by downregulation in many cancer types. Numerous cases have indicated that PCBP1 could be considered as a tumor suppressor to inhibit tumorigenesis, development, and metastasis. In the current review, we described the multilevel regulatory roles of PCBP1, including gene transcription, alternative splicing, and translation of many cancer‐related genes. Additionally, we also provided a brief overview about the inhibitory effect of PCBP1 on most common tumors. More importantly, we summarized the current research status about PCBP1 in hypoxic microenvironment, autophagy, apoptosis, and chemotherapy of cancer cells, aiming to clarify the molecular mechanisms of PCBP1 in cancer. Taken together, in‐depth study of PCBP1 in cancer may provide new ideas for cancer therapy.

中文翻译：

---

聚（rC）结合蛋白1在癌症中的多级调控和分子机制

聚 (rC) 结合蛋白 1 (PCBP1)，一种相对分子量为 38 kDa 的 RNA 或 DNA 结合蛋白，其特征是在许多癌症类型中下调。大量案例表明PCBP1可以被认为是抑制肿瘤发生、发展和转移的肿瘤抑制因子。在当前的综述中，我们描述了 PCBP1 的多级调控作用，包括基因转录、选择性剪接和许多癌症相关基因的翻译。此外，我们还简要概述了 PCBP1 对大多数常见肿瘤的抑制作用。更重要的是，我们总结了PCBP1在缺氧微环境、癌细胞自噬、凋亡、化疗等方面的研究现状，旨在阐明PCBP1在癌症中的分子机制。综合起来，