Advances in scarless foetal wound healing and prospects for scar reduction in adults,Cell Proliferation

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Advances in scarless foetal wound healing and prospects for scar reduction in adults
Cell Proliferation ( IF 5.9 ) Pub Date : 2020-10-15 , DOI: 10.1111/cpr.12916
Jia‐Li Yin _{1,

2} , Yan Wu _{1,

2} , Zheng‐Wei Yuan ₃ , Xing‐Hua Gao _{1,

2} , Hong‐duo Chen _{1,

2}

Affiliation

Healing after mammalian skin injury involves the interaction between numerous cellular constituents and regulatory factors, which together form three overlapping phases: an inflammatory response, a proliferation phase and a remodelling phase. Any slight variation in these three stages can substantially alter the healing process and resultant production of scars. Of particular significance are the mechanisms responsible for the scar‐free phenomenon observed in the foetus. Uncovering such mechanisms would offer great expectations in the treatment of scars and therefore represents an important area of investigation. In this review, we provide a comprehensive summary of studies on injury‐induced skin regeneration within the foetus. The information contained in these studies provides an opportunity for new insights into the treatment of clinical scars based on the cellular and molecular processes involved.

中文翻译：

胎儿无疤痕愈合的进展和成人疤痕减少的前景

哺乳动物皮肤损伤后的愈合涉及众多细胞成分和调节因子之间的相互作用，它们共同形成三个重叠阶段：炎症反应、增殖阶段和重塑阶段。这三个阶段的任何细微变化都会大大改变愈合过程和疤痕的产生。特别重要的是在胎儿中观察到的无疤痕现象的机制。揭示这种机制将为疤痕的治疗带来很大的期望，因此代表了一个重要的研究领域。在这篇综述中，我们对胎儿内损伤引起的皮肤再生的研究进行了全面总结。

更新日期：2020-10-15

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