Endothelial, pericyte and tumor cell expression in glioblastoma identifies fibroblast activation protein (FAP) as an excellent target for immunotherapy,Clinical & Translational Immunology

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Endothelial, pericyte and tumor cell expression in glioblastoma identifies fibroblast activation protein (FAP) as an excellent target for immunotherapy
Clinical & Translational Immunology ( IF 4.6 ) Pub Date : 2020-10-14 , DOI: 10.1002/cti2.1191
Lisa M Ebert _{1,

2} , Wenbo Yu ₁ , Tessa Gargett _{1,

2} , John Toubia ₁ , Paris M Kollis _{1,

2} , Melinda N Tea ₁ , Brenton W Ebert ₁ , Cedric Bardy _{3,

4} , Mark van den Hurk _{3,

4} , Claudine S Bonder _{1,

2} , Jim Manavis ₂ , Kathleen S Ensbey ₅ , Mariana Oksdath Mansilla ₁ , Kaitlin G Scheer _{1,

6} , Sally L Perrin _{1,

6} , Rebecca J Ormsby ₄ , Santosh Poonnoose _{4,

7} , Barbara Koszyca ₈ , Stuart M Pitson _{1,

2} , Bryan W Day _{5,

9,

10} , Guillermo A Gomez ₁ , Michael P Brown _{1,

2,

11}

Affiliation

Centre for Cancer Biology SA Pathology and University of South Australia Adelaide Australia.
Adelaide Medical School University of Adelaide Adelaide Australia.
South Australian Health and Medical Research Institute (SAHMRI) Adelaide Australia.
College of Medicine & Public Health Flinders University Adelaide Australia.
Department of Cell and Molecular Biology Sid Faithfull Brain Cancer Laboratory QIMR Berghofer Medical Research Institute Brisbane QLD Australia.
Clinical and Health Sciences University of South Australia Adelaide Australia.
Department of Neurosurgery Flinders Medical Centre Bedford Park Australia.
Department of Anatomical Pathology SA Pathology Adelaide Australia.
Faculty of Health Queensland University of Technology Brisbane QLD Australia.
Faculty of Medicine The University of Queensland Brisbane QLD Australia.
Cancer Clinical Trials Unit Royal Adelaide Hospital Adelaide Australia.

Targeted immunotherapies such as chimeric antigen receptor (CAR)‐T cells are emerging as attractive treatment options for glioblastoma, but rely on identification of a suitable tumor antigen. We validated a new target antigen for glioblastoma, fibroblast activation protein (FAP), by undertaking a detailed expression study of human samples.

中文翻译：

胶质母细胞瘤中的内皮细胞、周细胞和肿瘤细胞表达将成纤维细胞活化蛋白 (FAP) 鉴定为免疫治疗的极好靶点

嵌合抗原受体 (CAR)-T 细胞等靶向免疫疗法正在成为胶质母细胞瘤的有吸引力的治疗选择，但依赖于合适的肿瘤抗原的鉴定。我们通过对人类样本进行详细的表达研究，验证了胶质母细胞瘤的新靶抗原成纤维细胞活化蛋白 (FAP)。

更新日期：2020-10-16

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