Hippocampal subfield volumetry from structural isotropic 1 mm3 MRI scans: A note of caution,Human Brain Mapping

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Hippocampal subfield volumetry from structural isotropic 1 mm3 MRI scans: A note of caution
Human Brain Mapping ( IF 3.5 ) Pub Date : 2020-10-15 , DOI: 10.1002/hbm.25234
Laura E M Wisse _{1,

2,

3} , Gaël Chételat ₄ , Ana M Daugherty _{5,

6,

7} , Robin de Flores ₄ , Renaud la Joie ₈ , Susanne G Mueller _{9,

10} , Craig E L Stark ₁₁ , Lei Wang _{12,

13} , Paul A Yushkevich ₂ , David Berron ₁₄ , Naftali Raz _{5,

6,

15} , Arnold Bakker ₁₆ , Rosanna K Olsen ₁₇ , Valerie A Carr ₁₈

Affiliation

Diagnostic Radiology, Lund University, Lund, Sweden.
Penn Image Computing and Science Laboratory, Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Penn Memory Center, Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Université Normandie, Inserm, Université de Caen-Normandie, Inserm UMR-S U1237, Caen, France.
Department of Psychology, Wayne State University, Detroit, Michigan, USA.
Institute of Gerontology, Wayne State University, Detroit, Michigan, USA.
Department of Psychiatry and Behavioral Neurosciences, Wayne State University, Detroit, Michigan, USA.
Memory and Aging Center, University of California San Francisco, San Francisco, California, USA.
Department of Radiology, University of California San Francisco, San Francisco, California, USA.
Center for Imaging of Neurodegenerative Diseases, San Francisco VA Medical Center, San Francisco, California, USA.
Department of Neurobiology and Behavior, University of California Irvine, Irvine, California, USA.
Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Department of Radiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Clinical Memory Research Unit, Department of Clinical Sciences Malmö, Lund University, Lund, Sweden.
Center for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany.
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Rotman Research Institute, Baycrest Health Sciences, Toronto, Canada.
Department of Psychology, San Jose State University, San Jose, California, USA.

Spurred by availability of automatic segmentation software, in vivo MRI investigations of human hippocampal subfield volumes have proliferated in the recent years. However, a majority of these studies apply automatic segmentation to MRI scans with approximately 1 × 1 × 1 mm³ resolution, a resolution at which the internal structure of the hippocampus can rarely be visualized. Many of these studies have reported contradictory and often neurobiologically surprising results pertaining to the involvement of hippocampal subfields in normal brain function, aging, and disease. In this commentary, we first outline our concerns regarding the utility and validity of subfield segmentation on 1 × 1 × 1 mm³ MRI for volumetric studies, regardless of how images are segmented (i.e., manually or automatically). This image resolution is generally insufficient for visualizing the internal structure of the hippocampus, particularly the stratum radiatum lacunosum moleculare, which is crucial for valid and reliable subfield segmentation. Second, we discuss the fact that automatic methods that are employed most frequently to obtain hippocampal subfield volumes from 1 × 1 × 1 mm³ MRI have not been validated against manual segmentation on such images. For these reasons, we caution against using volumetric measurements of hippocampal subfields obtained from 1 × 1 × 1 mm³ images.

中文翻译：

结构各向同性 1 mm3 MRI 扫描的海马亚场体积：注意事项

近年来，在自动分割软件的推动下，对人类海马亚区体积的体内 MRI 研究激增。然而，这些研究大多数将自动分割应用于分辨率约为 1 × 1 × 1 mm ³的 MRI 扫描，在该分辨率下，海马内部结构很少能够可视化。其中许多研究报告了与海马亚区参与正常脑功能、衰老和疾病有关的相互矛盾且常常在神经生物学上令人惊讶的结果。在这篇评论中，我们首先概述了我们对 1 × 1 × 1 mm ³ MRI 子场分割在体积研究中的实用性和有效性的担忧，无论图像如何分割（即手动或自动）。这种图像分辨率通常不足以可视化海马体的内部结构，特别是辐射层腔隙分子，这对于有效和可靠的子场分割至关重要。其次，我们讨论了这样一个事实：最常用于从 1 × 1 × 1 mm ³ MRI 获取海马子场体积的自动方法尚未针对此类图像的手动分割进行验证。由于这些原因，我们警告不要使用从 1 × 1 × 1 mm ³图像获得的海马子区域的体积测量。

更新日期：2020-10-15

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