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Front Cover: SAR Studies of the Leupyrrins: Design and Total Synthesis of Highly Potent Simplified Leupylogs (Chem. Eur. J. 66/2020)
Chemistry - A European Journal ( IF 3.9 ) Pub Date : 2020-10-15 , DOI: 10.1002/chem.202003844 Paul R. Wosniok 1, 2 , Christopher Knopf 1, 3 , Sandra Dreisigacker 1, 4 , J. Manuel Orozco‐Rodriguez 5 , Bettina Hinkelmann 5 , Peter P. Mueller 5 , Mark Brönstrup 5 , Dirk Menche 1
Chemistry - A European Journal ( IF 3.9 ) Pub Date : 2020-10-15 , DOI: 10.1002/chem.202003844 Paul R. Wosniok 1, 2 , Christopher Knopf 1, 3 , Sandra Dreisigacker 1, 4 , J. Manuel Orozco‐Rodriguez 5 , Bettina Hinkelmann 5 , Peter P. Mueller 5 , Mark Brönstrup 5 , Dirk Menche 1
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The design and total synthesis of dramatically simplified leupylogs is presented. They demonstrate similar highly potent antifungal activities as the natural leupyrrins, as depicted by a balanced IC50 weighing scale. The origin of the secondary metabolites from the myxobacterium Sorangium cellulosum is illustrated by its fruiting bodies while the flask portrays the synthetic endeavors which have led to the discovery of leupylogs. More information can be found in the Communication by D. Menche et al. on page 15074.
中文翻译：
封面：Leupyrrins的SAR研究：高强度简化Leupylogs的设计和全合成（Eur。J. 66/2020）
介绍了大大简化的leupylogs的设计和总合成。它们表现出与天然亮丙菊酯类似的高效抗真菌活性，如平衡的IC 50秤所描绘的。粘胶细菌次生纤维素次生代谢产物的起源通过其子实体得以说明，而烧瓶则描绘了导致leupylogs发现的合成努力。可以在D. Menche等人的来文中找到更多信息。第15074页。
更新日期：2020-11-27
中文翻译：
封面：Leupyrrins的SAR研究：高强度简化Leupylogs的设计和全合成（Eur。J. 66/2020）
介绍了大大简化的leupylogs的设计和总合成。它们表现出与天然亮丙菊酯类似的高效抗真菌活性，如平衡的IC 50秤所描绘的。粘胶细菌次生纤维素次生代谢产物的起源通过其子实体得以说明，而烧瓶则描绘了导致leupylogs发现的合成努力。可以在D. Menche等人的来文中找到更多信息。第15074页。
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