Purine nucleotides regulate the cellular functions in the animal body. The current study evaluates the comparative efficacy of dietary purine nucleotides, that is, adenosine monophosphate (AMP), guanosine monophosphate (GMP) and inosine monophosphate (IMP) in red sea bream Pagrus major. Semi‐purified basal diet was formulated (Control, D1) containing 550 g/kg protein, supplemented with purine nucleotides AMP, GMP and IMP at their optimum supplementation level (2, 4 and 4 g/kg) to formulate the experimental diet groups D2, D3 and D4, respectively. Initial weight of 3.5 ± 0.01 g fish was randomly fed test diets in triplicate. After 56 days, % weight gain (p = .003), specific growth rate (p = .003) and apparent lipid digestibility (p = .04) were significantly higher in fish fed diet group D4 followed by D3 and D2. Supplemented groups showed significantly higher feed intake in comparison to control (p = .001). Supplemented groups showed significantly increased and decreased NBT (p = .003) and CAT (p = .003) activity, respectively. Fish fed IMP supplemented diets had significantly lower blood urea nitrogen (p = .04), glutamyl oxaloacetic transaminase (p = .04) and glutamic‐pyruvate transaminase (p = .001) followed by other supplemented groups. Supplemented diet groups showed enhanced stress resistance. Interestingly, D2 and D4 groups showed best oxidative stress status of fish. Therefore, these results indicated that among purine nucleotides, supplementation of IMP could be a more effective nucleotide as functional supplement in red sea bream diet.

中文翻译：

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嘌呤核苷酸腺苷，鸟嘌呤和肌苷一磷酸作为功能性补充剂对帕格鲁斯大红鲷生长和健康性能的功能比较评估

嘌呤核苷酸调节动物体内的细胞功能。目前的研究评估了日粮嘌呤核苷酸（即腺苷一磷酸（AMP），鸟苷一磷酸（GMP）和肌苷一磷酸（IMP））在红鲷鱼中的比较功效。配制了半纯净基础饮食（对照，D1），其中包含550 g / kg蛋白质，并以最佳补充水平（2、4和4 g / kg）补充了嘌呤核苷酸AMP，GMP和IMP，从而组成了实验饮食D2组，分别为D3和D4。初始体重为3.5±0.01 g的鱼一式三份随机喂食。56天后，体重增加百分比（p  = .003），比生长速率（p  = .003）和表观脂质消化率（p D4，D3和D2喂养的鱼饲料组中的= .04）显着更高。与对照组相比，补充组的采食量明显增加（p  = .001）。补充组分别显示出NBT（p  = .003）和CAT（p  = .003）活性显着增加和降低。补充IMP饮食的鱼的血尿素氮（p  = .04），谷氨酰草酰乙酸转氨酶（p  = .04）和谷氨酸丙酮酸转氨酶（p = .001），然后是其他补充组。补充饮食组显示出增强的抗逆性。有趣的是，D2和D4组显示出最佳的氧化应激状态。因此，这些结果表明，在嘌呤核苷酸中，补充IMP可能是红鲷鱼饮食中作为功能性补充剂更有效的核苷酸。