The present study aimed to analyze the nephroprotective property of violacein obtained from the bacterium, Chromobacterium violaceum. The nephrotoxicity in the animal model was induced by gentamicin, potassium dichromate, mercuric chloride, and cadmium chloride-induced nephrotoxicity in the Wistar rats was analyzed by measuring the serum creatinine, uric acid, and urea level. The present investigation revealed the nephroprotective property on convoluted proximal tubule (S1 and S2 segments) and the straight proximal tubule (S3 segment). Also, violacein significantly improved the renal function by the renal protective property on S2 segment of proximal tubule from the nephrotoxicity stimulated by mercuric chloride, potassium dichromate, cadmium chloride and gentamicin in animal models. Animal model studies revealed that violacein at 20 and 40 mg/kg p.o improved the renal function and significantly reduced the increased amount of uric acid, creatinine, and blood urea compared to the control.

本研究旨在分析从紫罗兰色杆菌中获得的紫罗素的肾保护特性。动物模型采用庆大霉素、重铬酸钾、氯化汞诱导，通过测定血清肌酐、尿酸、尿素水平分析氯化镉对Wistar大鼠的肾毒性。目前的研究揭示了近曲小管（S1 和 S2 段）和直近端小管（S3 段）的肾保护特性。此外，在动物模型中，紫罗兰素通过对近曲小管S2段的肾保护特性，显着改善肾功能，免受氯化汞、重铬酸钾、氯化镉和庆大霉素刺激的肾毒性。动物模型研究表明，与对照组相比，口服 20 和 40 mg/kg 紫罗兰素可改善肾功能，并显着降低尿酸、肌酐和血尿素的增加量。