Cell permeable, small molecule inhibitors are powerful tools for interrogating kinase function and validating drug targets. In this issue of Cell Chemical Biology, Liu and colleagues (2020) describe the development of a toolkit containing a highly selective DCLK1 inhibitor and complementary DCLK1 mutants for interrogating DCLK1-dependent cellular processes.

中文翻译：

---

适合工作的工具：用于查询 DCLK1 功能的化学和遗传工具包

可渗透细胞的小分子抑制剂是研究激酶功能和验证药物靶点的有力工具。在本期Cell Chemical Biology 中，Liu 及其同事 (2020) 描述了一种工具包的开发，该工具包包含高度选择性的 DCLK1 抑制剂和互补的 DCLK1 突变体，用于询问依赖于 DCLK1 的细胞过程。