CD19-specific CAR-T cell therapies are the gold standard of adoptive cellular immunotherapy for hematopoietic malignancies. In Science Translational Medicine, Park et al. develop an oncolytic vaccinia virus that introduces truncated CD19 expression in solid tumors, which are then eradicated by CD19-specific CAR-T cells in immunodeficient and immunocompetent mouse models.

中文翻译：

---

实体肿瘤的联合疗法：在新的冒险之旅中使用经典的汽车

CD19特异性CAR-T细胞疗法是用于造血系统恶性肿瘤的过继细胞免疫疗法的金标准。在《科学转化医学》中，Park等人。开发一种溶瘤牛痘病毒，该病毒在实体瘤中引入了截短的CD19表达，然后在免疫缺陷和具有免疫能力的小鼠模型中被CD19特异性CAR-T细胞消除。