Three extracts were produced from the above-ground part of the meadowsweet Filipendula ulmaria (L.) Maxim. using water, 40% ethanol, and 70% ethanol. Comparative assessment of their actions on the development of Lewis lung carcinoma (LLC) in C57Bl/6 mice showed that isolated administration led to inhibition of the development of the metastatic process by meadowsweet extracts prepared with water and 70% ethanol, with no effect on growth of the primary tumor. Comparative evaluation of the effects of meadowsweet extracts on the antitumor activity of cyclophosphamide (CP) in relation to primary tumors revealed no change in the efficacy of the cytostatic agent. Inclusion of meadowsweet extracts at doses of 25 and 50 mg/kg in the therapeutic regimen of mice with LLC produced significant increases in the antimetastatic action of CP using the aqueous extract (the indexes of inhibition of metastasis (IIM) were 75% and 98%). Meadowsweet extract prepared with 40% ethanol had no effect on the development of the tumor process in mice with LLC or the efficacy of CP treatment.

中文翻译：

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取决于提取剂的紫花菖蒲提取物的抗转移活性评估

从绣线菊 Filipendula ulmaria (L.) Maxim 的地上部分产生了三种提取物。使用水、40% 乙醇和 70% 乙醇。对它们对 C57Bl/6 小鼠刘易斯肺癌 (LLC) 发展的作用的比较评估表明，单独给药导致用水和 70% 乙醇制备的绣线菊提取物抑制转移过程的发展，对生长没有影响原发肿瘤。对绣线菊提取物对与原发肿瘤相关的环磷酰胺 (CP) 抗肿瘤活性的影响的比较评估显示，细胞抑制剂的功效没有变化。在 LLC 小鼠治疗方案中加入 25 和 50 mg/kg 的绣线菊提取物，使用水提取物显着增加了 CP 的抗转移作用（转移抑制指数 (IIM) 分别为 75% 和 98%） ）。用 40% 乙醇制备的绣线菊提取物对 LLC 小鼠肿瘤过程的发展或 CP 治疗的功效没有影响。