Label-free silver triangular nanoplates for spectrophotometric determination of catecholamines and their metabolites,Microchimica Acta

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Label-free silver triangular nanoplates for spectrophotometric determination of catecholamines and their metabolites
Microchimica Acta ( IF 5.3 ) Pub Date : 2020-10-15 , DOI: 10.1007/s00604-020-04576-1
Valeriy D Zaytsev ₁ , Aleksei A Furletov ₁ , Vladimir V Apyari ₁ , Alexey V Garshev _{1,

2} , Stanislava G Dmitrienko ₁ , Yury A Zolotov _{1,

3}

Affiliation

A novel method towards spectrophotometric determination of catecholamines and their metabolites differing in their functional groups has been developed. This method is based on a change in morphology of silver triangular nanoplates upon the action of cateсholamines and their metabolites, which is manifested by the decrease of the nanoparticle local surface plasmon resonance (LSPR) band intensity or its shift to the short-wavelength region of the spectrum. The shift value of the LSPR band or the change of its intensity increases with increasing concentration of catecholamines or their metabolites, which is proposed for their spectrophotometric determination. The limits of detection of catecholamines and their metabolites under selected conditions increase in the series homovanillic acid < vanillylmandelic acid < L-epinephrine < L-norepinephrine < dopamine and are 0.25, 1.2, 3.0, 64, and 130 μmol L−1, respectively. The selectivity of the proposed method was assessed using vanillylmandelic acid as example. It was found that the determination of vanillylmandelic acid does is not interfered in the presence of 4000-fold excess of Na+, K+, CH3COO−, and 1000-fold excess of Mg2+, Ca2+, Al3+, NO3−. The method also allows for the selective determination of vanillylmandelic acid in the presence of a 1000-fold excess of structurally related substances that do not contain either a catechol fragment or an electron donor substituent. The proposed approach was successfully applied to the determination of catecholamines in pharmaceuticals and artificial urine. Graphical abstract Graphical abstract

中文翻译：

用于分光光度法测定儿茶酚胺及其代谢物的无标记银三角纳米片

已经开发了一种分光光度法测定儿茶酚胺及其官能团不同的代谢物的新方法。该方法基于在儿茶酚胺及其代谢物的作用下银三角纳米片的形态变化，这表现为纳米粒子局部表面等离子体共振 (LSPR) 带强度的降低或其向频谱。LSPR 带的位移值或其强度的变化随着儿茶酚胺或其代谢物浓度的增加而增加，建议用于它们的分光光度测定。儿茶酚胺及其代谢物在选定条件下的检测限在以下系列中增加：高香草酸 < 香草扁桃酸 < L-肾上腺素 < L-去甲肾上腺素 < 多巴胺，分别为 0.25、1.2、3.0、64 和 130 μmol L-1。以香草扁桃酸为例，评估了所提出方法的选择性。结果表明，在存在 4000 倍过量的 Na+、K+、CH3COO− 和 1000 倍过量的 Mg2+、Ca2+、Al3+、NO3− 的情况下，香草扁桃酸的测定不会受到干扰。该方法还允许在不包含儿茶酚片段或电子供体取代基的 1000 倍过量的结构相关物质存在的情况下选择性测定香草扁桃酸。该方法已成功应用于药物和人工尿液中儿茶酚胺的测定。图形摘要图形摘要以香草扁桃酸为例，评估了所提出方法的选择性。结果表明，在存在 4000 倍过量的 Na+、K+、CH3COO− 和 1000 倍过量的 Mg2+、Ca2+、Al3+、NO3− 的情况下，香草扁桃酸的测定不会受到干扰。该方法还允许在不包含儿茶酚片段或电子供体取代基的 1000 倍过量的结构相关物质存在的情况下选择性测定香草扁桃酸。该方法已成功应用于药物和人工尿液中儿茶酚胺的测定。图形摘要图形摘要以香草扁桃酸为例，评估了所提出方法的选择性。结果表明，在存在 4000 倍过量的 Na+、K+、CH3COO− 和 1000 倍过量的 Mg2+、Ca2+、Al3+、NO3− 的情况下，香草扁桃酸的测定不会受到干扰。该方法还允许在不包含儿茶酚片段或电子供体取代基的 1000 倍过量的结构相关物质存在的情况下选择性测定香草扁桃酸。该方法已成功应用于药物和人工尿液中儿茶酚胺的测定。图形摘要图形摘要结果表明，在存在 4000 倍过量的 Na+、K+、CH3COO− 和 1000 倍过量的 Mg2+、Ca2+、Al3+、NO3− 的情况下，香草扁桃酸的测定不会受到干扰。该方法还允许在不包含儿茶酚片段或电子供体取代基的 1000 倍过量的结构相关物质存在的情况下选择性测定香草扁桃酸。该方法已成功应用于药物和人工尿液中儿茶酚胺的测定。图形摘要图形摘要结果表明，在存在 4000 倍过量的 Na+、K+、CH3COO− 和 1000 倍过量的 Mg2+、Ca2+、Al3+、NO3− 的情况下，香草扁桃酸的测定不会受到干扰。该方法还允许在不包含儿茶酚片段或电子供体取代基的 1000 倍过量的结构相关物质存在的情况下选择性测定香草扁桃酸。该方法已成功应用于药物和人工尿液中儿茶酚胺的测定。图形摘要图形摘要该方法还允许在不包含儿茶酚片段或电子供体取代基的 1000 倍过量的结构相关物质存在的情况下选择性测定香草扁桃酸。该方法已成功应用于药物和人工尿液中儿茶酚胺的测定。图形摘要图形摘要该方法还允许在不包含儿茶酚片段或电子供体取代基的 1000 倍过量的结构相关物质存在的情况下选择性测定香草扁桃酸。该方法已成功应用于药物和人工尿液中儿茶酚胺的测定。图形摘要图形摘要

更新日期：2020-10-15

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