Ion-substituted hydroxyapatite (HAP) offers several advantages compared with pure HAP. Since the calcium amount is relatively lower compared with the stoichiometric ratio of pure HAP, the resulting calcium deficiency in ion-substituted HAP leads to higher degradation in the physiological environment. Therefore, ion-substituted HAP has promising applications in the biomedical industry, particularly in drug delivery systems. In the present work, strontium-substituted HAP (Sr-HAP) was prepared by wet chemical precipitation method. The powders were characterized by X-ray diffraction (XRD) method and scanning electron microscopy (SEM). The crystallite size of Sr-HAP was calculated as ≈ 9 nm. Furthermore, structural characterization of Sr-HAP was done by Rietveld refinement and the substituting atomic sites and occupancies were obtained. The atomic positions occupied by the substituted Sr atoms in the calcium (Ca) atomic positions in the hcp unit cell were identified. The unit cell parameters of synthesized Sr-HAP were precisely calculated. The synthesized Sr-HAP powders were compacted and the antimicrobial properties were assessed by using Escherichia coli (E. coli) and Sporosarcina pasteurii (S. pasteurii). From the antimicrobial studies, it was understood that Sr-HAP has shown lower viability of these strains compared with pure HAP which is an indication of antimicrobial properties of Sr-HAP.

与纯HAP相比，离子取代的羟基磷灰石（HAP）具有许多优势。由于与纯HAP的化学计量比相比，钙的含量相对较低，因此离子取代的HAP中钙的缺乏会导致生理环境中的较高降解。因此，离子取代的HAP在生物医学行业，尤其​​是在药物输送系统中具有广阔的应用前景。在本工作中，通过湿化学沉淀法制备了锶取代的HAP（Sr-HAP）。通过X射线衍射（XRD）方法和扫描电子显微镜（SEM）对粉末进行表征。Sr-HAP的微晶尺寸计算为≈9 nm。此外，通过Rietveld精炼对Sr-HAP进行了结构表征，并获得了取代的原子位和占据率。确定了hcp晶胞。精确计算出合成的Sr-HAP的晶胞参数。将合成的锶磷灰石粉末通过使用压实和抗菌性能进行了评估大肠杆菌（大肠杆菌）和Sporosarcina巴氏（小号。巴氏）。从抗微生物研究中可以理解，与纯HAP相比，Sr-HAP已显示出这些菌株的活力较低，这表明Sr-HAP具有抗微生物特性。