Long non-coding RNAs (lncRNAs) have crucial roles in the pathogenesis of immune-related disorders. However, their role in the pathobiology of inflammatory demyelinating polyradiculoneuropathies remains unclear. In the current study, we measured peripheral expression of four lncRNAs, namely TUG1, FAS-AS1, NEAT1, and GAS5, in patients with acute/chronic inflammatory demyelinating polyradiculoneuropathies (AIDP/CIDP) compared with healthy subjects. Notably, all lncRNAs were over-expressed in patients compared with controls (P < 0.0001 for all lncRNAs). When assessing their expressions in AIDP and CIDP groups separately, TUG1 and NEAT1 were up-regulated in both patient groups compared with controls, yet FAS-AS1 and GAS5 were only up-regulated in CIDP cases. There were remarkable pairwise correlations between expression levels of these lncRNAs in all study groups. Based on the above-mentioned data, we suggest participation of these for lncRNAs in the pathogenesis of inflammatory demyelinating polyradiculoneuropathies. Moreover, FAS-AS1 and GAS5 lncRNAs have type-specific roles in this regard. Future functional studies are needed to elaborate the molecular mechanisms of the contribution of these transcripts in AIDP/CIDP.

长链非编码 RNA (lncRNA) 在免疫相关疾病的发病机制中起着至关重要的作用。然而，它们在炎性脱髓鞘性多发性神经根神经病的病理生物学中的作用仍不清楚。在目前的研究中，我们测量了急性/慢性炎症性脱髓鞘性多发性神经根神经病 (AIDP/CIDP) 患者与健康受试者相比的四种 lncRNA 的外周表达，即TUG1、FAS-AS1、NEAT1和GAS5。值得注意的是，与对照组相比，所有 lncRNA 在患者中均过表达（所有 lncRNA P < 0.0001）。分别评估他们在 AIDP 和 CIDP 组中的表达时，TUG1和NEAT1与对照组相比，在两个患者组中均上调，但FAS-AS1和GAS5仅在 CIDP 病例中上调。在所有研究组中，这些 lncRNA 的表达水平之间存在显着的成对相关性。基于上述数据，我们建议这些 lncRNAs 参与炎症性脱髓鞘性多发性神经根神经病的发病机制。此外，FAS-AS1和GAS5 lncRNA 在这方面具有特定类型的作用。需要未来的功能研究来阐述这些转录本在 AIDP/CIDP 中的贡献的分子机制。