Open Biology ( IF 4.5 ) Pub Date : 2020-10-14 , DOI: 10.1098/rsob.200112 Ananya Hariharan 1 , Suna Sun 1 , Martin Wipplinger 1 , Emanuela Felley-Bosco 1
RNA editing is a post-transcriptional process increasing transcript diversity, thereby regulating different biological processes. We recently observed that mutations resulting from RNA editing due to hydrolytic deamination of adenosine increase during the development of mesothelioma, a rare cancer linked to chronic exposure to asbestos. This review gathers information from the published literature and public data mining to explore several aspects of RNA editing and their possible implications for cancer growth and therapy. We address possible links between RNA editing and particular types of mesothelioma genetic and epigenetic alterations and discuss the relevance of an edited substrate in the context of current chemotherapy or immunotherapy.
中文翻译:
间皮瘤中的 RNA 编辑:展望
RNA 编辑是一个转录后过程,增加转录本的多样性,从而调节不同的生物过程。我们最近观察到,在间皮瘤(一种与长期接触石棉有关的罕见癌症)的发展过程中,由于腺苷的水解脱氨作用导致 RNA 编辑导致的突变增加。本综述从已发表的文献和公共数据挖掘中收集信息,以探讨 RNA 编辑的几个方面及其对癌症生长和治疗的可能影响。我们解决了 RNA 编辑与特定类型间皮瘤遗传和表观遗传改变之间可能的联系,并讨论了在当前化学疗法或免疫疗法的背景下编辑的底物的相关性。