Renal cell carcinoma (RCC) is one of the common urologic neoplasms, and its incidence has been increasing over the past several decades; however, its pathogenesis is still unknown up to now. Recent studies have found that in addition to tumor cells, other cells in the tumor microenvironment also affect the biological behavior of the tumor. Among them, macrophages exist in a large amount in tumor microenvironment, and they are generally considered to play a key role in promoting tumorigenesis. Therefore, we summarized the recent researches on macrophage in the invasiveness and progression of RCC in latest years, and we also introduced and discussed many studies about macrophage in RCC to promote angiogenesis by changing tumor microenvironment and inhibit immune response in order to activate tumor progression. Moreover, macrophage interactes with various cytokines to promote tumor proliferation, invasion and metastasis, and it also promotes tumor stem cell formation and induces drug resistance in the progression of RCC. The highlight of this review is to make a summary of the roles of macrophage in the invasion and progression of RCC; at the same time to raise some potential and possible targets for future RCC therapy.

肾细胞癌（RCC）是常见的泌尿科肿瘤，在过去的几十年中，其发病率一直在上升。然而，其发病机理至今仍未知。最近的研究发现，除肿瘤细胞外，肿瘤微环境中的其他细胞也影响肿瘤的生物学行为。其中，巨噬细胞在肿瘤微环境中大量存在，并且通常认为它们在促进肿瘤发生中起关键作用。因此，我们总结了近年来关于巨噬细胞在RCC的侵袭性和进展中的最新研究，并且我们还介绍和讨论了许多关于RCC中巨噬细胞通过改变肿瘤微环境来促进血管生成并抑制免疫应答以激活肿瘤进展的研究。此外，巨噬细胞与各种细胞因子相互作用以促进肿瘤增殖，侵袭和转移，并且还促进肿瘤干细胞的形成并在RCC的进展中诱导耐药性。综述的重点是总结巨噬细胞在RCC的侵袭和发展中的作用；同时为将来的RCC治疗提出一些潜在和可能的目标。