Gastric cancer (GC) is the fourth-most common cancer in the world, with an estimated 1.034 million new cases in 2015, and the third-highest cause of cancer deaths, estimated at 785,558, in 2014. Early diagnosis and treatment greatly affect the survival rate in patients with GC: the 5‐year survival rate of early GC reaches 90%‐95%, while the mortality rate significantly increases if GC develops to the late stage. Recently, studies for the role of RhoA in the diseases have become a hot topic, especially in the development of tumors. A study found that RhoA can regulate actin polymerization, cell adhesion, motor-myosin, cell transformation, and the ability to participate in the activities of cell movement, proliferation, migration, which are closely related to the invasion and metastasis of tumor cells. However, the specific role of RhoA in tumor cells remains to be studied. Therefore, our current study aimed to briefly review the role of RhoA in GC, especially for its associated signaling pathways involved in the GC progression.

胃癌（GC）是世界上第四大常见癌症，2015年估计有10.34百万新病例，并且是2014年第三大癌症死亡原因，估计为785,558。早期诊断和治疗极大地影响了胃癌。胃癌患者的生存率：早期胃癌的5年生存率达到90％-95％，而如果胃癌发展到晚期，死亡率会显着增加。最近，关于RhoA在疾病中的作用的研究已成为热门话题，尤其是在肿瘤的发展中。一项研究发现，RhoA可以调节肌动蛋白的聚合，细胞粘附，运动肌球蛋白，细胞转化以及参与细胞运动，增殖，迁移活动的能力，而这些活动与肿瘤细胞的侵袭和转移密切相关。然而，RhoA在肿瘤细胞中的具体作用仍有待研究。因此，我们目前的研究旨在简要回顾RhoA在GC中的作用，特别是其与GC进展相关的信号通路。