Simvastatin, lovastatin, rosuvastatin, pravastatin and cerivastatin belong to the statin family, which are competitive inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A. As the rate-limiting enzyme in the pathway of cholesterol metabolism, statins are classically prescribed to patients as lipidlowering agents. However, statins also possess several extra bioactivities, including anti-inflammatory, antiviral and anti-tumor. Interestingly, the most essential mechanism of these activities is that statins could regulate the expression of cell adhesion molecules (CAMs), especially, targeting lymphocytes function-associated molecules (LFA)-1, macrophage (Mac)-1 and intercellular adhesion molecules (ICAM)-1. Therefore, in this paper, we discussed the regulatory effect of statins on CAMs among different diseases. In addition, we provided speculation for the role of statins in treating orthopedic disease.

辛伐他汀，洛伐他汀，瑞舒伐他汀，普伐他汀和西立伐他汀属于他汀类，它们是3-羟基-3-甲基戊二酰辅酶A的竞争性抑制剂。作为胆固醇代谢途径中的限速酶，他汀类药物通常向患者开具以下处方：降脂药。然而，他汀类药物还具有几种额外的生物活性，包括抗炎，抗病毒和抗肿瘤。有趣的是，这些活性的最基本机制是他汀类药物可以调节细胞粘附分子（CAMs）的表达，尤其是针对淋巴细胞功能相关分子（LFA）-1，巨噬细胞（Mac）-1和细胞间粘附分子（ICAM） -1。因此，在本文中，我们讨论了他汀类药物对不同疾病中CAM的调节作用。此外，