Heroin is one of the most frequently seized drugs in the South-Eastern Europe. Due to the position in the Balkan route, the Republic of Serbia keeps important role in suppression of the trafficking of heroin for domestic and foreign illegal market. This research is aimed to provide a good scientific approach in the field of seized heroin analysis. Two different forms of heroin are present in the illegal market, mostly in mixtures with typical "cutting" agents: caffeine, paracetamol and sugars. It was observed that the quantity of pure heroin in seized samples slightly increases from year to year. The aim of this study was to produce a reliable and fast procedure for classification of illicit heroin samples and determination of the concentration range of heroin in the samples. For that purpose the Fourier Transformed Infrared Spectroscopy (ATR technique) was used and combined with chemometric methods (PCA, CA, PLS). Principal components analysis (PCA), as an unsupervised model, was used for exploratory purposes, to identify trends, similarities and differences between samples, by reducing the dimensionality of the data. The cluster classification of examined samples turned out to be extremely useful to evaluate the possibilities of the ATR-FTIR technique to classify the samples appropriately into the patterns, the constituted clusters. Additionally PLS was the suitable method for the purpose of determination of the heroin hydrochloride concentration range in examined samples. It is proved that the joined application of spectroscopy and chemometrics can be extremely convenient and useful for forensic and drugs control laboratories.

中文翻译：

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EXPRESS：化学计量学方法对复杂的海洛因混合物进行快速衰减全反射傅立叶变换红外分析

海洛因是东南欧最常缉获的毒品之一。由于处于巴尔干路线，塞尔维亚共和国在打击为国内外非法市场贩运海洛因方面发挥着重要作用。本研究旨在为缉获的海洛因分析领域提供一种良好的科学方法。非法市场上存在两种不同形式的海洛因，主要与典型的“切割”剂混合在一起：咖啡因、扑热息痛和糖。据观察，检获样本中纯海洛因的数量逐年略有增加。本研究的目的是为非法海洛因样品的分类和确定样品中海洛因的浓度范围提供可靠和快速的程序。为此目的，使用傅立叶变换红外光谱（ATR 技术）并结合化学计量方法（PCA、CA、PLS）。主成分分析 (PCA) 作为一种无监督模型，用于探索性目的，通过降低数据的维度来识别样本之间的趋势、相似性和差异。检查样品的聚类分类对于评估 ATR-FTIR 技术将样品适当地分类为模式，即构成的聚类的可能性非常有用。此外，PLS 是确定检查样品中海洛因盐酸盐浓度范围的合适方法。