During development, neurons extend in search of synaptic partners. Precise control of axon extension velocity can therefore be crucial to ensuring proper circuit formation. How velocity is regulated - particularly by the extending axons themselves - remains poorly understood. Here, we investigate this question in the Drosophila visual system, where photoreceptors make precise connections with a specific set of synaptic partners that together create a circuit underpinning neural superposition (NSP). We used a combination of genetic perturbations and quantitative image analysis to investigate the influence of cell identity on growth cone velocity and subsequent spatial-temporal coincidence of presynaptic and postsynaptic neurons. Our study provides a case study of how cell autonomous properties of presynaptic axons play a pivotal role in controlling the dynamics of growing axons and determining the formation of a precise neuronal circuit.

中文翻译：

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关于感光体识别在控制果蝇视觉电路正确布线中的作用

在发育过程中，神经元扩展以寻找突触伴侣。因此，精确控制轴突延伸速度对于确保正确形成回路至关重要。如何调节速度-尤其是通过延伸的轴突本身-仍然知之甚少。在这里，我们在果蝇中调查这个问题视觉系统，其中感光器与一组特定的突触伙伴建立精确连接，这些伙伴共同创建了支持神经叠加（NSP）的电路。我们使用遗传扰动和定量图像分析的组合来研究细胞身份对突触前和突触后神经元的生长锥速度和随后的时空重合的影响。我们的研究提供了一个案例研究，说明突触前轴突的细胞自主特性如何在控制生长轴突的动力学和确定精确的神经元回路的形成中起关键作用。