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Tunable LCST/UCST-Type Polypeptoids and Their Structure–Property Relationship
Biomacromolecules ( IF 5.5 ) Pub Date : 2020-10-14 , DOI: 10.1021/acs.biomac.0c01177 Xiaohui Fu 1 , Chao Xing 1 , Jing Sun 1
Biomacromolecules ( IF 5.5 ) Pub Date : 2020-10-14 , DOI: 10.1021/acs.biomac.0c01177 Xiaohui Fu 1 , Chao Xing 1 , Jing Sun 1
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Bioinspired thermoresponsive polymeric materials with tunable phase-transition behaviors are highly desirable for biomedical applications. Here, we reported a facile approach for the synthesis of both lower critical solution temperature (LCST) and upper critical solution temperature (UCST) types of thermoresponsive polypeptoids with tunable phase-transition temperature in the range of 29––55 °C. The introduction of alkyl groups and ethylene glycol (EG) units results in a controlled phase-transition behavior under fairly mild conditions. A very sharp transition (ΔT ≤ 1.5 °C) is observed by simply adjusting pH and the alkyl chain length. In particular, the carboxyl-containing polypeptoids display designable UCST behavior, which can be finely tuned in both water and methanol. All these features make the obtained polymers beneficial for practical applications. More interestingly, we demonstrate that the hydrophilic EG group behaves as an excellent regulator to tune the UCST behavior, while the hydrophobic alkyl residues show remarkable capability to regulate the LCST behavior of the system. We hope that such systematic structure–property studies will enable the design of smart polymer materials to meet the specific needs of future applications.
中文翻译：
可调谐LCST / UCST型多肽及其结构与性质的关系
具有可调相变行为的受生物启发的热响应聚合物材料是生物医学应用中非常需要的。在这里，我们报道了一种简便的方法，用于合成具有可调相变温度范围为29–55°C的热响应性类肽的下临界溶液温度（LCST）和上临界溶液温度（UCST）类型。烷基和乙二醇（EG）单元的引入在相当温和的条件下导致受控的相变行为。非常陡峭的过渡（ΔT≤1.5°C）仅通过调节pH和烷基链长即可观察到。尤其是，含羧基的类多肽显示出可设计的UCST行为，可以在水和甲醇中对其进行微调。所有这些特征使得所获得的聚合物对实际应用有益。更有趣的是，我们证明了亲水性EG基团可作为调节UCST行为的出色调节剂，而疏水性烷基残基则具有出色的调节系统LCST行为的能力。我们希望这种系统的结构-性能研究将使智能聚合物材料的设计能够满足未来应用的特定需求。
更新日期：2020-12-14
中文翻译：
可调谐LCST / UCST型多肽及其结构与性质的关系
具有可调相变行为的受生物启发的热响应聚合物材料是生物医学应用中非常需要的。在这里，我们报道了一种简便的方法，用于合成具有可调相变温度范围为29–55°C的热响应性类肽的下临界溶液温度（LCST）和上临界溶液温度（UCST）类型。烷基和乙二醇（EG）单元的引入在相当温和的条件下导致受控的相变行为。非常陡峭的过渡（ΔT≤1.5°C）仅通过调节pH和烷基链长即可观察到。尤其是，含羧基的类多肽显示出可设计的UCST行为，可以在水和甲醇中对其进行微调。所有这些特征使得所获得的聚合物对实际应用有益。更有趣的是，我们证明了亲水性EG基团可作为调节UCST行为的出色调节剂，而疏水性烷基残基则具有出色的调节系统LCST行为的能力。我们希望这种系统的结构-性能研究将使智能聚合物材料的设计能够满足未来应用的特定需求。
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