SummarySpermatogenesis is an androgen-dependent event, and testosterone is the major androgen source. The enzyme 5-alpha reductase converts testosterone to dihydrotestosterone (DHT) in testicular and peripheral tissues. Polymorphisms in genes encoding 5-alpha reductase may be associated with impaired male fertility. The present study aimed to investigate the relationship between 5-alpha reductase type 2 (SRD5A2) gene rs523349 polymorphism and non-obstructive azoospermia (NOA) in Turkish patients. The study included 75 NOA patients and 43 fertile men from Turkey. No significant relationship was found between SRD5A2 gene rs523349 polymorphism and male infertility (P = 0.071). There was a statistically significant difference in total testosterone level and total testis volume between NOA patients and the control groups, however there was no significant difference between serum follicle-stimulating hormone and luteinizing hormone levels. Our results showed that SRD5A2 gene rs523349 polymorphism was not associated with NOA in Turkish patients.

中文翻译：

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5-阿尔法还原酶 2 型 (SRD5A2) 基因 rs523349 多态性与土耳其患者的非梗阻性无精子症无关

摘要精子发生是一种雄激素依赖性事件，而睾酮是主要的雄激素来源。5-α 还原酶在睾丸和外周组织中将睾酮转化为二氢睾酮 (DHT)。编码 5-α 还原酶的基因的多态性可能与男性生育能力受损有关。本研究旨在探讨 2 型 5-α 还原酶 (SRD5A2) 基因 rs523349 多态性和土耳其患者的非阻塞性无精子症 (NOA)。该研究包括来自土耳其的 75 名 NOA 患者和 43 名有生育能力的男性。之间未发现显着关系SRD5A2rs523349基因多态性与男性不育症（磷= 0.071)。NOA患者与对照组的总睾酮水平和总睾丸体积差异有统计学意义，但血清促卵泡激素和促黄体激素水平无显着差异。我们的结果表明SRD5A2基因 rs523349 多态性与土耳其患者的 NOA 无关。