The regulation of gene expression is a promising therapeutic approach for many intractable diseases. However, its use in clinical applications requires the efficient delivery of nucleic acids to target tissues, which is a major challenge. Recently, various delivery systems employing physical energy, such as ultrasound, magnetic force, electric force, and light, have been developed. Ultrasound-mediated delivery has particularly attracted interest due to its safety and low costs. Its delivery effects are also enhanced when combined with microbubbles or nanobubbles that entrap an ultrasound contrast gas. Furthermore, ultrasound-mediated nucleic acid delivery could be performed only in ultrasound exposed areas. In this review, we summarize the ultrasound-mediated nucleic acid systemic delivery system, using microbubbles or nanobubbles, and discuss its possibilities as a therapeutic tool.

中文翻译：

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超声微泡和纳米泡用于系统基因传递。

基因表达的调节是许多顽固性疾病的有前途的治疗方法。然而，其在临床应用中的使用要求将核酸有效地递送至靶组织，这是主要挑战。近来，已经开发了利用诸如超声波，磁力，电力和光之类的物理能量的各种递送系统。超声介导的递送由于其安全性和低成本而特别引起人们的兴趣。当与捕获超声造影剂气体的微气泡或纳米气泡结合使用时，其递送效果也得到增强。此外，超声介导的核酸递送只能在超声暴露的区域进行。在这篇综述中，我们总结了使用微泡或纳米泡的超声介导的核酸全身递送系统，