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Structure, Formation, and Biological Interactions of Supported Lipid Bilayers (SLB) Incorporating Lipopolysaccharide
Coatings ( IF 3.4 ) Pub Date : 2020-10-14 , DOI: 10.3390/coatings10100981
Palak Sondhi , Dhanbir Lingden , Keith J. Stine

Biomimetic membrane systems play a crucial role in the field of biosensor engineering. Over the years, significant progress has been achieved creating artificial membranes by various strategies from vesicle fusion to Langmuir transfer approaches to meet an ever-growing demand for supported lipid bilayers on various substrates such as glass, mica, gold, polymer cushions, and many more. This paper reviews the diversity seen in the preparation of biologically relevant model lipid membranes which includes monolayers and bilayers of phospholipid and other crucial components such as proteins, characterization techniques, changes in the physical properties of the membranes during molecular interactions and the dynamics of the lipid membrane with biologically active molecules with special emphasis on lipopolysaccharides (LPS).

中文翻译:

脂多糖结合脂质双分子层(SLB)的结构,形成和生物相互作用。

仿生膜系统在生物传感器工程领域中起着至关重要的作用。多年来,通过从囊泡融合到Langmuir转移方法的各种策略,在满足人工对膜,玻璃,云母,金,聚合物垫等多种衬底上支持的脂质双层的不断增长的需求方面,在制造人造膜方面已经取得了重大进展。 。本文综述了在生物相关模型脂质膜的制备中所观察到的多样性,该模型包括磷脂的单层和双层以及蛋白质,表征技术,膜在分子相互作用过程中物理性质的变化以及脂质动力学等其他关键成分具有生物活性分子的膜,尤其着重脂多糖(LPS)。
更新日期:2020-10-14
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