Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is the causative agent of the coronavirus disease 2019 (COVID-19) pandemic spreading around the world, causing massive distress to the world’s economy and affecting healthcare systems worldwide. Although some exposed individuals have no symptoms and most symptomatic infections are not severe, COVID-19 cases span a wide spectrum, ranging from mild to critical and sometimes resulting in life-threatening complications, such as pneumonia, severe respiratory distress and cardiac problems. Currently, there is no curative drug for COVID-19 and vaccines are still under development. We are presenting here a strategy for the fast development of natural live-attenuated SARS-CoV-2 vaccines. Our proposed approach is based on screening for, identifying, analyzing and selecting naturally attenuated yet highly immunogenic SARS-CoV-2 strains, which may lead to a shorter cycle of vaccine development, as well as higher vaccine effectiveness.

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快速开发SARS-CoV-2减毒活疫苗的可能途径：突入天然库

严重急性呼吸系统综合症冠状病毒2（SARS-CoV-2）是2019年冠状病毒病（COVID-19）大流行的致病因子，在世界范围内蔓延，对世界经济造成了巨大困扰，并影响了全球医疗系统。尽管一些裸露的个体没有症状，大多数症状性感染并不严重，但COVID-19病例范围很广，从轻度到严重，有时会导致危及生命的并发症，如肺炎，严重的呼吸窘迫和心脏问题。当前，尚无用于COVID-19的治疗药物，疫苗仍在开发中。我们在此提出一种快速开发天然减毒活SARS-CoV-2疫苗的策略。我们提出的方法是基于筛选，识别，