Abstract

Background

Cognitive decline can develop into mild cognitive impairment, a high-risk factor in the progression of Alzheimer’s disease. The antioxidant micronutrient selenium may have some effect on preventing cognitive decline, but the association between whole blood selenium concentration and cognitive function remains controversial.

Aim

To investigate the association between whole blood selenium concentration and cognitive function score in elderly Americans.

Subjects and methods

Data was obtained from the national health and nutrition survey between 2011 and 2014. A general linear model was used to adjust for possible risk factors to analyse the association between blood selenium concentration and cognitive function.

Results

2068 participants were included in our study, and the average blood selenium concentration was high at 195.08 μg/L. The risk of lower cognitive scores was higher in people with lower blood selenium concentration (p < 0.05). The lower cognition may also be associated with one or more of the following characteristics: older, male, had a low poverty-income ratio, low education level, and consumed less alcohol. Related conditions such as stroke, diabetes and high blood pressure may also affect cognitive scores.

Conclusions

Higher blood selenium is associated with higher cognitive scores in elderly Americans.

中文翻译：

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一项针对美国老年人血硒浓度和认知功能的横断面研究：2011-2014年美国国家健康与营养检查

摘要

背景

认知能力下降可发展为轻度认知障碍，这是阿尔茨海默氏病进展的高风险因素。抗氧化剂微量营养素硒可能对预防认知功能下降有一定作用，但全血硒浓度与认知功能之间的关系仍存在争议。

目标

调查全血硒浓度与美国老年人认知功能评分之间的关​​系。

主题与方法

数据来自2011年至2014年的全国健康和营养调查。使用通用线性模型调整可能的危险因素，以分析血硒浓度与认知功能之间的关系。

结果

我们的研究纳入了2068名参与者，平均血硒浓度高达195.08μg/ L。血液中硒浓度较低的人认知得分较低的风险较高（p  <0.05）。较低的认知水平也可能与以下一个或多个特征有关：年龄较大，男性，贫困收入比低，教育水平低，饮酒少。中风，糖尿病和高血压等相关疾病也可能影响认知评分。

结论

较高的血液硒含量与老年美国人的较高认知得分相关。