Abstract

Five new secoiridoid glycosides, cornusphenosides E-I (1–5), were isolated and characterized from an active fraction of ethanol extract of the fruits of Cornus officinalis. Their structures were determined by extensive spectroscopic data analysis, including 2 D NMR and HRESIMS experiments. In the preliminary assay, compound 5 (when evaluated at 10 μM) showed the neuroprotective effect against H₂O₂-induced SH-SY5Y cell damage.

中文翻译：

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山茱萸果实中的类环烯醚萜苷

摘要

从山茱萸果实的乙醇提取物的活性部分中分离和表征了五种新的secioridoid糖苷，cornusphenosides EI ( 1-5 )。它们的结构是通过广泛的光谱数据分析确定的，包括 2 D NMR 和 HRESIMS 实验。在初步测定中，化合物5 （当以10μM评估时 ）显示出针对H ₂ O ₂诱导的SH-SY5Y细胞损伤的神经保护作用。