Social contact deficit is considered a stressful circumstance associated with various neural, hormonal, genetic, immune, and behavioral effects. A growing body of clinical and basic science evidence suggests that social isolation is linked to a higher risk of various neurological, cardiovascular, and metabolic diseases, including hypertension, diabetes mellitus, and obesity. However, the impact of the deficit of social interaction on kidney function is not well established. The Dahl salt-sensitive (SS) rat is a classical model of salt-induced hypertension and associated kidney injury. In this study, we investigated the effect of one-month social isolation (SI) on blood and urine electrolytes, metabolic, physiological, and behavioral parameters in adolescent male Dahl SS rats fed a normal 0.4 % NaCl diet. SI rats demonstrated increased behavioral excitability compared with rats kept in groups. We also observed increased food consumption and a decrease in plasma leptin levels in SI group without differences in water intake and weight gain compared with grouped animals. No changes in the level of blood and urine electrolytes, 24 hr urine output, creatinine clearance, and albumin/creatinine ratio were identified between the SI and grouped rats. These findings indicate that one-month social isolation of adolescent Dahl SS rats affects metabolic parameters but has no apparent influence on kidney function.

中文翻译：

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青春期雄性Dahl盐敏感性大鼠隔离一个月的行为，代谢和肾脏结局

社会交往不足被认为是与各种神经，激素，遗传，免疫和行为影响相关的压力环境。越来越多的临床和基础科学证据表明，社会隔离与各种神经系统疾病，心血管疾病和代谢疾病（包括高血压，糖尿病和肥胖症）的较高风险相关。然而，社交互动不足对肾脏功能的影响尚不明确。达尔盐敏感性（SS）大鼠是盐诱导的高血压和相关肾脏损害的经典模型。在这项研究中，我们调查了一个月社会隔离（SI）对以正常0.4％NaCl饮食喂养的青春期雄性Dahl SS大鼠的血液和尿液电解质，代谢，生理和行为参数的影响。与分组饲养的大鼠相比，SI大鼠表现出增强的行为兴奋性。我们还观察到，与分组动物相比，SI组的食物消耗增加且血浆瘦素水平降低，而饮水量和体重增加没有差异。在SI和分组大鼠之间，未发现血液和尿液电解质水平，24小时尿量，肌酐清除率和白蛋白/肌酐比值发生变化。这些发现表明，青春期Dahl SS大鼠进行社会隔离一个月会影响代谢参数，但对肾脏功能没有明显影响。在SI和分组大鼠之间，未发现血液和尿液电解质水平，24小时尿量，肌酐清除率和白蛋白/肌酐比值发生变化。这些发现表明青春期Dahl SS大鼠的一个月社会隔离影响代谢参数，但对肾脏功能没有明显影响。在SI和分组大鼠之间，未发现血液和尿液电解质水平，24小时尿量，肌酐清除率和白蛋白/肌酐比值发生变化。这些发现表明，青春期Dahl SS大鼠进行社会隔离一个月会影响代谢参数，但对肾脏功能没有明显影响。