The menopausal transition is associated with increased prevalence of hypertension, and in time postmenopausal women (PMW) will exhibit a cardiovascular disease risk-score similar to male counterparts. Hypertension is associated with vascular dysfunction, but whether hypertensive PMW have blunted nitric-oxide (NO)-mediated leg vasodilator responsiveness, and whether this is reversible by high-intensity training (HIT) is unknown. To address these questions, we examined the leg vascular conductance (LVC) in response to femoral-infusion of acetylcholine (ACh) and sodium nitroprusside (SNP), and skeletal muscle markers of oxidative stress and NO bioavailability before and after HIT in PMW (12.9±6.0 (mean±SD) years since last menstrual cycle). We hypothesized that ACh- and SNP-induced LVC responsiveness was reduced in hypertensive compared to normotensive PMW and that 10 weeks of HIT would reverse the blunted LVC response and decrease blood pressure (BP).Nine hypertensive (HYP; clinical systolic/diastolic BP 149±11/91±83 mmHg) and 8 normotensive (NORM; 122±13/75±8 mmHg) PMW completed 10 weeks of bi-weekly small-sided floorball training (4-5x3-5 min interspersed by 1-3 min rest periods). Before training, the SNP-induced change in LVC was lower (P<0.05) in HYP compared with NORM. With training, the ACh- and SNP-induced change in LVC at maximal infusion rates i.e. 100 and 6 μg∙min-1∙kg leg mass-1, respectively, improved (P<0.05) in HYP only. Further, training decreased (P<0.05) clinical systolic/diastolic BP (-15±11/-9±7 mmHg) in HYP, and systolic BP (-10±9 mmHg) in NORM. Thus, the SNP-mediated LVC responsiveness was blunted in hypertensive PMW, and reversed by a period of HIT that was associated with a marked decrease in clinical BP.

中文翻译：

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高血压与NO介导的腿部血管舒张剂钝化反应有关，而绝经后妇女通过高强度训练可逆转这种反应

绝经过渡期与高血压患病率增加有关，绝经后妇女（PMW）将及时显示出与男性相对应的心血管疾病风险评分。高血压与血管功能障碍有关，但是高血压的PMW是否具有减弱的一氧化氮（NO）介导的腿部血管舒张反应，以及高强度训练（HIT）是否可逆。为了解决这些问题，我们检查了对股骨输注乙酰胆碱（ACh）和硝普钠（SNP）的腿部血管电导（LVC），以及在PMW中HIT前后氧化应激和NO生物利用度的骨骼肌标志物（12.9）自上次月经周期以来的±6.0（平均±SD）年。我们假设高血压与正常血压PMW相比，ACh和SNP诱导的LVC反应性降低，HIT的10周将逆转钝化的LVC反应并降低血压（BP）.9高血压（HYP;临床收缩/舒张压BP 149 ±11/91±83 mmHg）和8个血压正常（NORM; 122±13/75±8 mmHg）的PMW完成了为期10周的双周小侧地板球训练（4-5x3-5分钟，穿插1-3分钟休息）期）。训练前，HNP的SNP诱导的LVC改变低于NORM（P <0.05）。通过训练，在最大输注速率下，分别由ACh和SNP引起的LVC变化（分别为100和6μg∙min-1∙kg腿质量-1）仅在HYP中得到改善（P <0.05）。此外，训练降低了HYP的临床收缩/舒张血压（-15±11 / -9±7 mmHg）（P <0.05），而NORM降低了收缩压（-10±9 mmHg）。从而，