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The clinical characteristics and prognosis of COVID‐19 patients with cerebral stroke: A retrospective study of 113 cases from one single‐centre
European Journal of Neuroscience ( IF 2.7 ) Pub Date : 2020-10-14 , DOI: 10.1111/ejn.15007 Xiaolong Yao 1, 2 , Shengwen Liu 1 , Junwen Wang 1 , Kai Zhao 1 , Xiaobing Long 1 , Xuejun He 1 , Huicong Kang 1 , Yiping Yang 1 , Xiaopeng Ma 1 , Pengjie Yue 1 , Kai Shu 1 , Zhouping Tang 3 , Ting Lei 1 , Jihong Liu 4 , Wei Wang 3 , Huaqiu Zhang 1
European Journal of Neuroscience ( IF 2.7 ) Pub Date : 2020-10-14 , DOI: 10.1111/ejn.15007 Xiaolong Yao 1, 2 , Shengwen Liu 1 , Junwen Wang 1 , Kai Zhao 1 , Xiaobing Long 1 , Xuejun He 1 , Huicong Kang 1 , Yiping Yang 1 , Xiaopeng Ma 1 , Pengjie Yue 1 , Kai Shu 1 , Zhouping Tang 3 , Ting Lei 1 , Jihong Liu 4 , Wei Wang 3 , Huaqiu Zhang 1
Affiliation
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To explore the clinical characteristics and prognosis of COVID‐19 patients with cerebral stroke. A total of 2,474 COVID‐19 patients from February 10th to March 24th, 2020 were admitted and treated in two branches (Optic Valley and Sino‐French New City branch) of the Tongji Hospital. Data on the clinical characteristics, laboratory parameters and prognosis of COVID‐19 patients with or without cerebral stroke were collected and comparatively analysed. Of the 2,474 COVID‐19 patients, 113 (4.7%) patients had cerebral stroke and 25 (1.0%) patients had new‐onset stroke. Eighty‐eight (77.9%) patients in the previous‐stroke group had cerebral ischaemia, while 25 (22.1%) patients in the new‐onset stroke group had cerebral ischaemia. Most COVID‐19 patients with stroke were elderly with more comorbidities such as hypertension, diabetes and heart diseases than patients without stroke. Laboratory examinations showed hypercoagulation and elevated serum parameters such as IL‐6, cTnI, NT pro‐BNP and BUN. Consciousness disorders, a long disease course and poor prognosis were also more commonly observed in stroke patients. The mortality rate of stroke patients was almost double (12.4% vs. 6.9%) that of patients without stroke. In addition, age, male sex and hypertension were independent predictors for new cerebral stroke in COVID‐19 patients. In conclusion, the high risk of new‐onset stroke must be taken into consideration when treating COVID‐19 patients with an elderly age combined with a history of hypertension. These patients are more vulnerable to multiorgan dysfunction and an overactivated inflammatory response, in turn leading to an unfavourable outcome and higher mortality rate.
中文翻译：
COVID-19脑卒中患者的临床特征和预后：对单中心113例的回顾性研究
探讨COVID-19脑卒中患者的临床特征和预后。从2020年2月10日至3月24日，共2474名COVID-19患者入院并在同济医院的两个分支机构（光学谷和中法新城市分支机构）接受治疗。收集并比较分析有关COVID-19伴或不伴脑卒中患者的临床特征，实验室参数和预后的数据。在2474名COVID-19患者中，有113名（4.7％）有脑卒中，有25名（1.0％）有新发中风。卒中前组中有88名（77.9％）患者患有脑缺血，而新发卒中组中有25名（22.1％）患者患有脑缺血。大多数COVID-19卒中患者是老年人，合并症如高血压，糖尿病和心脏病比没有中风的患者多。实验室检查显示高凝和血清参数升高，例如IL-6，cTnI，NT pro-BNP和BUN。在中风患者中也更常观察到意识障碍，病程长和预后不良。中风患者的死亡率几乎是无中风患者的两倍（12.4％比6.9％）。此外，年龄，男性和高血压是COVID-19患者新发脑卒中的独立预测因子。总之，在治疗高龄合并高血压病史的COVID-19患者时，必须考虑到新发中风的高风险。这些患者更容易遭受多器官功能障碍和过度激活的炎症反应，
更新日期：2020-10-14
中文翻译：
COVID-19脑卒中患者的临床特征和预后：对单中心113例的回顾性研究
探讨COVID-19脑卒中患者的临床特征和预后。从2020年2月10日至3月24日，共2474名COVID-19患者入院并在同济医院的两个分支机构（光学谷和中法新城市分支机构）接受治疗。收集并比较分析有关COVID-19伴或不伴脑卒中患者的临床特征，实验室参数和预后的数据。在2474名COVID-19患者中，有113名（4.7％）有脑卒中，有25名（1.0％）有新发中风。卒中前组中有88名（77.9％）患者患有脑缺血，而新发卒中组中有25名（22.1％）患者患有脑缺血。大多数COVID-19卒中患者是老年人，合并症如高血压，糖尿病和心脏病比没有中风的患者多。实验室检查显示高凝和血清参数升高，例如IL-6，cTnI，NT pro-BNP和BUN。在中风患者中也更常观察到意识障碍，病程长和预后不良。中风患者的死亡率几乎是无中风患者的两倍（12.4％比6.9％）。此外，年龄，男性和高血压是COVID-19患者新发脑卒中的独立预测因子。总之，在治疗高龄合并高血压病史的COVID-19患者时，必须考虑到新发中风的高风险。这些患者更容易遭受多器官功能障碍和过度激活的炎症反应，
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