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Limited effect of duration of CMV infection on adaptive immunity and frailty: insights from a 27‐year‐long longitudinal study
Clinical & Translational Immunology ( IF 5.8 ) Pub Date : 2020-10-14 , DOI: 10.1002/cti2.1193
Leonard Daniël Samson 1, 2, 3 , Sara Ph van den Berg 1, 4 , Peter Engelfriet 2 , Annemieke Mh Boots 3 , Marion Hendriks 1 , Lia Gh de Rond 1 , Mary-Lène de Zeeuw-Brouwer 1 , Wm Monique Verschuren 2, 5 , José Am Borghans 4 , Anne-Marie Buisman 1 , Debbie van Baarle 1, 4
Affiliation  

Cytomegalovirus infection is thought to affect the immune system and to impact general health during ageing. Higher CMV‐specific antibody levels in the elderly are generally assumed to reflect experienced viral reactivation during life. Furthermore, high levels of terminally differentiated and CMV‐specific T cells are hallmarks of CMV infection, which are thought to expand over time, a process also referred to as memory inflation.

中文翻译:

CMV 感染持续时间对适应性免疫和虚弱的影响有限:来自一项长达 27 年的纵向研究的见解

巨细胞病毒感染被认为会影响免疫系统并在衰老过程中影响整体健康。通常认为老年人中较高的 CMV 特异性抗体水平反映了生命中经历的病毒再激活。此外,高水平的终末分化和 CMV 特异性 T 细胞是 CMV 感染的标志,它被认为会随着时间的推移而扩大,这一过程也称为记忆膨胀。
更新日期:2020-10-14
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