Intercellular movement of plant RNA viruses: Targeting replication complexes to the plasmodesma for both accuracy and efficiency,Traffic

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Intercellular movement of plant RNA viruses: Targeting replication complexes to the plasmodesma for both accuracy and efficiency
Traffic ( IF 3.6 ) Pub Date : 2020-10-14 , DOI: 10.1111/tra.12768
Xiaoyun Wu ₁ , Xiaofei Cheng ₁

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Replication and movement are two critical steps in plant virus infection. Recent advances in the understanding of the architecture and subcellular localization of virus‐induced inclusions and the interactions between viral replication complex (VRC) and movement proteins (MPs) allow for the dissection of the intrinsic relationship between replication and movement, which has revealed that recruitment of VRCs to the plasmodesma (PD) via direct or indirect MP‐VRC interactions is a common strategy used for cell‐to‐cell movement by most plant RNA viruses. In this review, we summarize the recent advances in the understanding of virus‐induced inclusions and their roles in virus replication and cell‐to‐cell movement, analyze the advantages of such coreplicational movement from a viral point of view and discuss the possible mechanical force by which MPs drive the movement of virions or viral RNAs through the PD. Finally, we highlight the missing pieces of the puzzle of viral movement that are especially worth investigating in the near future.

中文翻译：

植物 RNA 病毒的细胞间运动：将复制复合物靶向胞间连丝以提高准确性和效率

复制和运动是植物病毒感染的两个关键步骤。对病毒诱导内含物的结构和亚细胞定位以及病毒复制复合物（VRC）和运动蛋白（MP）之间相互作用的理解的最新进展允许剖析复制和运动之间的内在关系，这揭示了招募VRC 通过直接或间接 MP-VRC 相互作用到达胞间连丝 (PD) 是大多数植物 RNA 病毒细胞间运动的常见策略。在这篇综述中，我们总结了对病毒诱导的包涵体及其在病毒复制和细胞间运动中的作用的最新进展，从病毒的角度分析了这种共复制运动的优势，并讨论了可能的机械力MP 通过 PD 驱动病毒粒子或病毒 RNA 的运动。最后，我们强调了病毒传播之谜中缺失的部分，这些部分在不久的将来特别值得研究。

更新日期：2020-11-16

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