Concise Total Syntheses of Bioactive Alkaloids Enabled by Development or Application of Cascade Reactions: A Personnel Adventure,Chinese Journal of Chemistry

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Concise Total Syntheses of Bioactive Alkaloids Enabled by Development or Application of Cascade Reactions: A Personnel Adventure
Chinese Journal of Chemistry ( IF 5.5 ) Pub Date : 2020-10-14 , DOI: 10.1002/cjoc.202000522
Xingang Xie ₁ , Xuegong She ₁

Affiliation

Design and development of new tactics and strategies to improve synthetic efficiency is a hot topic and main concern in nowadays’ chemical synthesis of bioactive natural products. Cascade reactions, which construct several bonds in one step via an orchestrated sequence, have been regarded as an important tactic to rapidly increase the molecular complexity, therefor to improve the synthetic efficiency. In this perspective account, we demonstrated and highlighted the significance of cascade reaction developments and applications in concise syntheses of bioactive alkaloids based on our own recent adventure in this research field.

中文翻译：

通过开发或应用级联反应实现的生物活性生物碱的简明全合成：人员冒险

设计和开发提高合成效率的新策略和策略是当今生物活性天然产物的化学合成中的一个热门话题和主要关注点。级联反应通过一个精心安排的序列一步构建几个键，已经被认为是一种快速增加分子复杂性，从而提高合成效率的重要策略。在这个观点的说明中，我们根据本领域的最新探索，论证并强调了级联反应的发展和在简明生物活性生物碱合成中的应用的重要性。

更新日期：2020-10-14

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