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Identification of the stable and reactive metabolites of tetrahydropiperine using ultrahigh‐performance liquid chromatography combined with diode‐array detection and high‐resolution mass spectrometry
Rapid Communications in Mass Spectrometry ( IF 1.8 ) Pub Date : 2020-10-13 , DOI: 10.1002/rcm.8975
Xiaoling Chen 1 , Yanghua Li 2
Affiliation  

Tetrahydropiperine is one of the natural arylpentanamide compounds isolated from Piper nigrum L., which has been demonstrated to have insecticidal activity. The aim of this study was to investigate the metabolic profiles of tetrahydropiperine in mouse, rat, dog, monkey and human hepatocytes.

中文翻译:

超高效液相色谱结合二极管阵列检测和高分辨率质谱鉴定四氢胡椒碱的稳定和反应性代谢产物

四氢胡椒碱是从胡椒胡椒中分离得到的天然芳基戊酰胺化合物之一,已证明具有杀虫活性。这项研究的目的是研究四氢胡椒碱在小鼠,大鼠,狗,猴和人肝细胞中的代谢特征。
更新日期:2020-11-22
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