To present a system for the treatment of prostate cancer in a single‐fraction regimen using ¹⁶⁹Yb‐based rotating shield brachytherapy (RSBT) with a single‐catheter robotic delivery system. The proposed system is innovative because it can deliver RSBT through multiple implanted needles independently, in serial, using flexible catheters, with no inter‐needle shielding effects and without the need to rotate multiple shielded catheters inside the needles simultaneously, resulting in a simple, mechanically robust, delivery approach. RSBT was compared to conventional ¹⁹²Ir‐based high‐dose‐rate brachytherapy (HDR‐BT) in a treatment planning study with dose escalation and urethral sparing goals, representing single‐fraction brachytherapy monotherapy and brachytherapy as a boost to external beam radiotherapy, respectively. A prototype mechanical delivery system was constructed and quantitatively evaluated as a proof of concept.

中文翻译：

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基于 169Yb 的旋转盾构近距离治疗前列腺癌

提出一种单次治疗前列腺癌的系统，该系统使用基于¹⁶⁹ Yb 的旋转屏蔽近距离放射治疗 (RSBT) 和单导管机器人输送系统。所提出的系统具有创新性，因为它可以使用柔性导管独立、串行地通过多个植入针头输送 RSBT，没有针间屏蔽效应，也不需要同时在针头内旋转多个屏蔽导管，从而实现了一种简单、机械稳健的交付方式。RSBT 与传统^192相比基于 Ir 的高剂量率近距离放射治疗 (HDR-BT) 在具有剂量递增和保留尿道目标的治疗计划研究中，分别代表单次近距离放射治疗单一治疗和近距离放射治疗作为外照射放射治疗的推动力。构建了一个原型机械输送系统，并作为概念验证进行了定量评估。